蛋白质聚集在白内障发病中的作用研究进展  

Research progress of the action of protein aggregation in cataract development

作　　者：郭昭兴 万修华 GUO Zhaoxing;WAN Xiuhua(Beijing Tongren Eye Center,Beijing Tongren Hospital of Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,北京市100005

出　　处：《眼科新进展》2024年第1期76-81,共6页Recent Advances in Ophthalmology

基　　金：国家自然科学基金项目(编号:82171037);北京市医院管理中心临床医学发展专项经费资助项目(编号:XMLX202133)。

摘　　要：蛋白质聚集在白内障发病过程中扮演着重要角色。近年来,基因测序技术和其他分子生物学技术广泛应用于蛋白质聚集现象的研究,其内在机制被逐渐阐明。基因突变、异构化与共价修饰、化合物和离子作用、蛋白质相互作用均是蛋白质聚集发生的原因。本文围绕上述四点对蛋白质聚集在白内障发病中的作用研究进展进行综述,以期为后续研究提供资料和参考。Protein aggregation plays an essential role in the development of cataracts.In recent years,gene sequencing and other molecular biological techniques have been widely used in the study of protein aggregation,whose intrinsic mechanisms have been gradually elucidated.Gene mutations,isomerization and covalent modifications,compound and ionic interactions,and protein interactions are all causes of protein aggregation.This article focuses on the above four causes to review the research progress on the effect of protein aggregation in the development of cataracts,so as to provide information and reference for subsequent studies.

关 键 词：晶状体蛋白 白内障 基因突变 共价修饰 蛋白质相互作用 

分 类 号：R776.1[医药卫生—眼科]