Echinacoside attenuates glandular fibrosis in benign prostatic hyperplasia via inhibiting MKK6/MK2 signaling pathway  

作　　者：Si Qin Jing-Lou Chen Xiao-Feng Zhou Cong-Yue Xu Jing Guo 

机构地区：[1]Department of Pharmacy,Jianghan University,Wuhan 430056,China [2]Department of Clinical Medicine,Jianghan University,Wuhan 430056,China [3]Institutes of Biomedical Sciences,Jianghan University,Wuhan 430056,China [4]Department of Basic Medicine,School of Medicine,Jianghan University,Wuhan 430056,China

出　　处：《Traditional Medicine Research》2024年第3期24-31,共8页TMR传统医学研究

基　　金：supported by the Research Fund of Jianghan University(grant number 2023KJZX23).

摘　　要：Background:Lower urinary tract symptoms commonly occur in the elderly population and seriously constrain the quality of life.Glandular fibrosis is an important pathobiological process in benign prostatic hyperplasia and is also a main inducing factor for benign prostatic hyperplasia-associated lower urinary tract symptoms.Cistanches species is an important herbal medicine resource and is traditionally used in ameliorating renal and prostatic defects.Methods:This study was to investigate the potential protective function of echinacoside(a bioactive compound from Cistanches)against prostatic fibrosis in mice and human benign prostatic hyperplasia epithelial-1 cell models.Results:It was found that echinacoside attenuated testosterone-induced prostatic hyperplasia and collagen deposition in mice,relieved prostate local inflammation and oxidative damage,and ameliorated prostatic epithelial-mesenchymal transition.Additionally,echinacoside inhibited the activation of the MKK6/MK2 signaling pathway both in vivo and in vitro.Conclusion:This study added new evidence for the anti-fibrotic function of echinacoside on the prostate and provided new insights for understanding its possible pharmacological mechanisms.

关 键 词：benign prostatic hyperplasia ECHINACOSIDE epithelial-mesenchymal transition FIBROSIS 

分 类 号：R285[医药卫生—中药学]