植物甾醇酯红曲软胶囊的处方与工艺研究  

Study on the Prescription and Preparation of Phytosterol Esters Red Yeast Rice Soft Capsule

作　　者：黎宇盛 刘春芳 陈亮 李菁 曾荣华 许文东 袁诚 韩亚明 Li Yusheng;Liu Chunfang;Chen Liang;Li Jing;Zeng Ronghua;Xu Wendong;Yuan Cheng;Han Yaming(Guangzhou Hanfang Pharmaceutical Co.,Ltd.,National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation,Guangdong Provincial Key Laboratory of Medicinal Lipid,Guangzhou 510240,China)

机构地区：[1]广州白云山汉方现代药业有限公司,中药制药过程技术与新药创制国家工程研究中心,广东省药用脂质重点实验室,广东广州510240

出　　处：《广东化工》2023年第23期1-5,共5页Guangdong Chemical Industry

基　　金：广东省药用脂质重点实验室(2020B1212070024)。

摘　　要：背景:红曲是我国传统的药食同源中药材之一,其药食两用价值极高,复配植物甾醇酯开发成辅助降血脂的保健食品具有相当的现实意义。目的:优选植物甾醇酯红曲软胶囊最佳制备工艺。方法:运用超声提取法富集红曲的有效活性成分,并制备成红曲-磷脂复合物,采用单因素试验分别对软胶囊的内容物及囊壳的处方进行筛选。结果:确定了超声提取红曲的最佳工艺条件为乙醇浓度70%,料液比为1∶10,提取时间为30 min,提取温度为50℃,超声频率为210 W。内容物处方为植物甾醇酯∶红曲∶蜂蜡:大豆油=8.7∶4.2∶1∶14,囊壳处方为明胶∶甘油∶水∶二氧化钛∶焦糖色素=1∶0.4∶1∶0.007∶0.007。结论:该软胶囊的制备工艺可行,质量可控,适合工业化生产。Background:Red yeast rice is one of the traditional Chinese medicinal materials with the same origin as medicine and food.Its value of both medicine and food is very high.It is of practical significance to develop the compound phytosterol ester into health food to assist in lowering blood lipid.Objective:To optimize the prescription and preparation of phytosterol esters red yeast rice soft capsules.Methods:The active components in red yeast rice were extracted by ultrasonic,and the red yeast rice-phospholipid complex was prepared.The prescriptions of content and capsule were screened by single factor test.Results:The optimal extraction conditions were 70%ethanol concentration,1∶10 solid-liquid ratio,30 min extraction time,50℃extraction temperature and 210W ultrasonic frequency.The optimal formulation of the content was phytosterol ester-red yeast rice-beeswax-soybean oil,with a ratio of 8.7∶4.2∶1∶14.The optimal formulation of capsule shell was gelatin-glycerin-water-titanium dioxide-caramel pigment,with a ratio of 1∶0.4∶1∶0.007∶0.007.Conclusion:The preparation process of the soft capsule is feasible,the quality is controllable,and it is suitable for industrial production.

关 键 词：植物甾醇酯 红曲 超声提取 软胶囊 制备工艺 

分 类 号：TQ[化学工程]