OBE教育理念下药物化学实验设计:双丹皮酚缩1,3-丙二胺席夫碱的合成  

Experimental Design in Medicinal Chemistry under OBE Education Concept:Synthesis of Schiff base Bis-(Paeonol)-[1,3-Propylenediamine]

作　　者：高雷雷 王芳 陈艳君 王威 李国四 韩邦兴[1] 刘东[1] Gao Leilei;Wang Fang;Chen Yanjun;Wang Wei;Li Guosi;Han Bangxing;Liu Dong(West Anhui University,Luan 237012,China)

机构地区：[1]皖西学院,安徽六安237012

出　　处：《广东化工》2023年第24期145-147,共3页Guangdong Chemical Industry

基　　金：安徽省高校省级质量工程项目(2022xxkc141,2022jcbs064,2020szsfkc0928);皖西学院校级质量工程项目(wxxy2022123)。

摘　　要：药物化学实验课程是高等院校药学、药物制剂等药学相关专业的重要实验课程,其能让学生更好的了解药物设计原理、药物的合成过程,有助于学生理论知识应用于实践,提高学生学习兴趣。本文基于OBE教育理念,通过结合药物化学理论课程中的重点内容,设计了双丹皮酚缩1,3-丙二胺席夫碱合成实验,该实验涉及药物化学中前药重点概念以及薄层层析法、重结晶、减压抽滤、熔点检测等药物合成基本实验操作技能,不仅能加深学生对重点知识的理解和记忆,还可以激发学生学习理论知识兴趣,增强学生实验技能以及科研思维,为后续学生专业知识的学习打下牢固的基础。Medicinal chemistry experimental is an important experimental course for pharmacy,pharmaceutical preparation,pharmaceutical engineering and other pharmacy-related majors in colleges and universities,which enables students to better understand the principles of drug design,the synthesis process of drugs,and helps students to apply their theoretical knowledge to practice,and improves their interest in learning medicinal chemistry.In this paper,based on the concept of OBE education,an experiment on the synthesis of Schiff base Bis-(Paeonol)-[1,3-Propylenediamine]is designed by combining the key contents in the theoretical course of medicinal chemistry.The experiment involves the key concepts of prodrugs in medicinal chemistry as well as the basic experimental operation skills of drug synthesis such as thin-layer chromatography,recrystallization,decompression filtration,melting point detection etc.It not only deepens the students'understanding and memory of the key professional knowledge,but also stimulates the students'interest in learning the theoretical knowledge,strengthens the students'experimental skills as well as their scientific research thinking,and lays a solid foundation for the subsequent learning of the students'professional knowledge.

关 键 词：OBE教育理念 药物化学 实验设计 合成 双丹皮酚缩1 3-丙二胺席夫碱 

分 类 号：G420[文化科学—课程与教学论] G642[文化科学—教育学]