lncRNA与急性髓系白血病中常见基因突变之间关系的研究进展  

Research progress on the relationship between long non-coding RNA and common gene mutations in acute myeloid leukemia

作　　者：沈亦扬 刘玉思 刘璇[1] 符爽 张继红[1] SHEN Yiyang;LIU Yusi;LIU Xuan;FU Shuang;ZHANG Jihong(Hematology Laboratory,Shengjing Hospital,China Medical University,Liaoning Shenyang 110022,China)

机构地区：[1]中国医科大学附属盛京医院血液研究室,辽宁沈阳110022

出　　处：《现代肿瘤医学》2024年第1期181-188,共8页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:82070165)。

摘　　要：长链非编码RNA(long non-coding RNA,lncRNA)作为新兴分子,近年来在急性髓系白血病(acute myeloid leukemia,AML)的发病机制、预后、耐药等领域备受关注。基因突变作为AML预后判断和治疗的重要靶点,已有大量的研究积累。本文将结合AML中lncRNA研究的最新报道,梳理lncRNA与AML中常见基因突变的关系,回顾两者对AML发生发展的影响,为临床诊断和治疗AML提供新的参考和思路。As emerging molecules,long non-coding RNAs(lncRNAs) have attracted much attention in pathogenesis,prognosis and drug resistance of acute myeloid leukemia(AML) in recent years.As an important indicator for prognosis and treatment target of AML,gene mutation has been extensively studied.This review is to summarizes the latest reports of lncRNA researches,and to sort out the relationship between lncRNAs and common mutations in AML,as well as the effects of both on the occurrence and development of AML,therefor to provide reference and ideas for clinical diagnosis and treatment of AML.

关 键 词：长链非编码RNA 急性髓系白血病 基因突变 

分 类 号：R733[医药卫生—肿瘤]