Oxidized Dopamine Acrylamide Primer to Achieve Durable Resin-Dentin Bonding  

作　　者：Leping Wu Hui Shao Yang Tao Jingya Wu Xinhui Wang Qiufeng Nian Shunli Zheng Chris Ying Cao Yuancong Zhao Zheng Zhou Hai Ming Wong Quan-Li Li 

机构地区：[1]Key Laboratory of Oral Diseases Research of Anhui Province,College and Hospital of Stomatology,Anhui Medical University,81 Meishan Road,Hefei 230032,China [2]The Affiliated Jiangning Hospital with Nanjing Medical University,Nanjing,Jiangsu 211100,China [3]Key Laboratory of Advanced Technology for Materials of Education Ministry,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China [4]School of Dentistry,University of Detroit Mercy,Detroit,MI 48208-2576,USA [5]Faculty of Dentistry,The University of Hong Kong,34 Hospital Road,The Prince Philip Dental Hospital,Hong Kong 999077,China

出　　处：《Research》2023年第4期539-555,共17页研究（英文）

基　　金：This work was supported by the National Natural Sci-ence Foundation of China,China(No.81970983,No.82061160492,and No.82101070);The University Synergy Innovation Pro-gram of Anhui Province(GXXT-2021-062);2021 Disciplinary Construction Project in School of Dentistry,Anhui Medical University(2021kqxkFY14);Anhui Provincial Natural Science Foundation(No.2008085QH374);Key Research and Develop-ment Plan of Anhui Province(No.2022e07020051);and Re-search Fund of Anhui Institute of Translational Medicine(No.2021zhyx-C51).

摘　　要：The durability of the resin-dentin bonding interface is a key issue in clinical esthetic dentistry.Inspired by the extraordinary bioadhesive properties of marine mussels in a wet environment,we designed and synthetized N-2-(3,4-dihydroxylphenyl)acrylamide(DAA)according to the functional domain of mussel adhesive proteins.DAA’s properties of collagen cross-linking,collagenase inhibition,inducing collagen mineralization in vitro,and as a novel prime monomer for clinical dentin adhesion use,its optimal parameters,and effect on the adhesive longevity and the bonding interface’s integrity and mineralization,were evaluated in vitro and in vivo.The results showed that oxide DAA can inhibit the activity of collagenase and cross collagen fibers to improve the anti-enzymatic hydrolysis of collagen fibers and induce intrafibrillar and interfibrillar collagen mineralization.As a primer used in the etch-rinse tooth adhesive system,oxide DAA can improve the durability and integrity of the bonding interface by anti-degradation and mineralization of the exposed collagen matrix.Oxidized DAA(OX-DAA)is a promising primer for improving dentin durability;using 5%OX-DAA ethanol solution and treating the etched dentin surface for 30 s is the optimal choice when used as a primer in the etch-rinse tooth adhesive system.

关 键 词：DURABILITY BONDING interface 

分 类 号：R78[医药卫生—口腔医学]