Comprehensive analysis of sodium polystyrene sulfonate-induced colitis:A systematic review  

作　　者：Gabriel Peixoto Aver Guilherme Ferreira Ribeiro Vinícius Remus Ballotin Francisco Souza dos Santos Lucas Goldmann Bigarella Floriano Riva Eduardo Brambilla Jonathan Soldera 

机构地区：[1]School of Medicine,Universidade de Caxias do Sul,Caxias do Sul 95070-560,Brazil [2]Department of Pathology,CPM Laboratório de Patologia,Caxias do Sul 95084-900,RS,Brazil [3]Clinical Gastroenterology,Universidade de Caxias do Sul,Caxias do Sul 95070-560,RS,Brazil [4]Acute Medicine and Gastroenterology,University of South Wales,Cardiff CF371DL,United Kingdom

出　　处：《World Journal of Meta-Analysis》2023年第7期351-367,共17页世界荟萃分析杂志

摘　　要：BACKGROUND Sodium polystyrene sulfonate(SPS)is commonly prescribed for the management of hyperkalemia,a critical electrolyte imbalance contributing to over 800000 annual visits to emergency departments.AIM To conduct a systematic review of documented cases of SPS-induced colitis and assess its associated prognosis.METHODS Following the PRISMA-P guidelines,our study employed Medical Subject Headings and Health Sciences Descriptors,skillfully combined using Boolean operators,to conduct comprehensive searches across various electronic databases,including Scopus,Web of Science,MEDLINE(PubMed),BIREME(Biblioteca Regional de Medicina),LILACS(Latin American and Caribbean Health Sciences Literature),SciELO(Scientific Electronic Library Online),Embase,and Opengray.eu.Language criteria were confined to English,Spanish,and Portuguese,with no limitations on the publication date.Additionally,we manually scrutinized the reference lists of retrieved studies.To present our findings,we utilized simple descriptive analysis.RESULTS Our search strategy yielded a total of 442 references.After rigorous evaluation,we included 51 references,encompassing 59 documented cases of colitis.Predominant clinical presentations included abdominal pain,observed in 35(60.3%)cases,and bloating,reported in 18(31%)cases.The most frequently affected sites of inflammation were the cecum,rectum,and small intestine,accounting for 31%,25.8%,and 22.4%of cases,respectively.Colonoscopy findings were described in 28(48.2%)cases,and 29(50%)of patients required surgical intervention.Among the subset of patients for whom outcome data was available,39(67.2%)experienced favorable outcomes,while 12(20.6%)unfortunately succumbed to the condition.The mean time required for resolution was 36.7 d,with a range spanning from 1 to 120 d.CONCLUSION SPS demonstrates the capacity to effectively lower serum potassium levels within 24 h.However,this benefit is not without the risk of bowel injury.Our study highlights the absence of high-quality data pertaining to the incidence o

关 键 词：Sodium polystyrene sulfonate HYPERKALEMIA COLITIS Bowel necrosis Kayexalate 

分 类 号：R57[医药卫生—消化系统]