Multifunctional roles of inflammation and its causative factors in primary liver cancer:A literature review  

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作  者:Hong-Jin Chen Ting-Xiong Huang Yu-Xi Jiang Xiong Chen Ai-Fang Wang 

机构地区:[1]Department of Pharmacology,School of Basic Medical Sciences,Translational Medicine Research Center,Guizhou Medical University,Guiyang 550025,Guizhou Province,China [2]School of Clinical Medical,Translational Medicine Research Center,Guizhou Medical University,Guiyang 550025,Guizhou Province,China [3]Zhejiang Provincial Key Laboratory of Medical Genetics,Key Laboratory of Laboratory Medicine,Ministry of Education,Wenzhou 325035,Zhejiang Province,China [4]Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [5]Department of Endocrinology,The People's Hospital of Yuhuan,The Yuhuan Branch of The First Affiliated Hospital of Wenzhou Medical University,Yuhuan 317600,Zhejiang Province,China

出  处:《World Journal of Hepatology》2023年第12期1258-1271,共14页世界肝病学杂志(英文版)(电子版)

基  金:Supported by the National Natural Science Foundation of China,No.82260567;Science and Technology Fund of Guizhou Provincial Health Commission,No.gzwkj2022-082;Excellent Young Talents Plan of Guizhou Medical University,No.2023(112);Taizhou Social Development Science and Technology Plan Project,No.23ywb146;and Start-up Fund of Guizhou Medical University,No.J2021032.

摘  要:Primary liver cancer is a severe and complex disease,leading to 800000 global deaths annually.Emerging evidence suggests that inflammation is one of the critical factors in the development of hepatocellular carcinoma(HCC).Patients with viral hepatitis,alcoholic hepatitis,and steatohepatitis symptoms are at higher risk of developing HCC.However,not all inflammatory factors have a pathogenic function in HCC development.The current study describes the process and mechanism of hepatitis development and its progression to HCC,particularly focusing on viral hepatitis,alcoholic hepatitis,and steatohepatitis.Furthermore,the roles of some essential inflammatory cytokines in HCC progression are described in addition to a summary of future research directions.

关 键 词:INFLAMMATION Primary liver cancer Hepatocellular carcinoma Nonalcoholic fatty liver disease Hepatitis virus 

分 类 号:R73[医药卫生—肿瘤]

 

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