Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor drugs  

Natural isothiocyanates of the genus Capparis as potential agonists of apoptosis and antitumor

作　　者：Lumír Hanuš Tuvia Naor Tatyana Gloriozova Valery M Dembitsky 

机构地区：[1]Institute for Drug Research,School of Pharmacy,Faculty of Medicine,Hebrew University,Ein Kerem Campus,Jerusalem 91120,Israel [2]Food Chemistry,Kibbutz,Yotvata 8882000,Israel [3]Department of Bioinformatics,Institute of Biomedical Chemistry,Moscow 119121,Russia [4]Centre for Applied Research and Innovation,Lethbridge College,Lethbridge AB T1K 1L6,Canada

出　　处：《World Journal of Pharmacology》2023年第4期35-52,共18页世界药理学杂志

摘　　要：BACKGROUND Using gas chromatography-mass spectrometry(GC/MS)analysis,we examined the composition of volatile components present in the yellow and green fruits,seeds,and jam of the scrambling shrub Capparis cartilaginea(C.cartilaginea).These plant samples were collected from Kibbutz Yotvata in Israel.In all the tested samples,isothiocyanates were identified.Utilizing the PASS program,we ascertained the biological activity of these isothiocyanates present in the Capparis genus.The study results highlighted that all isothiocyanates could potentially act as apoptosis agonists,making them strong candidates for antitumor drugs.This information holds significant value for the fields of medicinal chemistry,pharmacology,and practical medicine.AIM To investigate the volatile components present in the yellow and green fruits,seeds,and jam of the C.cartilaginea shrub using GC/MS analysis,to detect isothiocyanates in all the analyzed plant samples,and to assess the biological activity of these isothiocyanates utilizing the PASS program.METHODS We utilized two primary methods to analyze the volatile compounds present in the yellow and green fruits,seeds,and jams of the C.cartilaginea,native to Israel.We identified biologically active isothiocyanates in these samples.Their anticipated biological activities were determined using the PASS program,with the most dominant activities being apoptosis agonist,anticarcinogenic,and antineoplastic specifically for genitourinary cancer.RESULTS Fruits,seeds,and jams containing isothiocyanates,which exhibit antineoplastic and anticarcinogenic activities,could be suggested for cancer prevention and management.Specific isothiocyanates,with therapeutic potential in this realm,could be recommended as potent anticancer agents in practical medicine following clinical trials.CONCLUSION The discovery that isothiocyanates exhibit potent antineoplastic and anticarcinogenic activities was unexpected.Additionally,certain isothiocyanates demonstrated antifungal,antiviral(specifically against arbovirus),a

关 键 词：Capparis cartilaginea FRUITS Seeds ISOTHIOCYANATES APOPTOSIS ANTICANCER 

分 类 号：R73[医药卫生—肿瘤]