Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor  

作　　者：Hyo-Geun Lee H.H.A.C.K.Jayawardhana Fengqi Yang D.P.Nagahawaththa N.M.Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang 

机构地区：[1]Department of Marine Life Sciences,Jeju National University,Jeju 63243,Republic of Korea [2]Marine Science Institute,Jeju National University,Jeju 63333,Republic of Korea [3]Research Group of Food Processing,Korea Food Research Institute,Wanju 55365,Republic of Korea [4]Department of Pharmoceutical Engineering,Soonchunhyang University,Asan 31538,Republic of Korea

出　　处：《Food Science and Human Wellness》2024年第3期1608-1616,共9页食品科学与人类健康（英文）

基　　金：The“Basic Science Research Program”extended its support via the National Research Foundation of Korea (NRF),which is sponsored through the Ministry of Education (2018R1C1B6004780);supported by Main Research Program (E0211200-03)of the Korea Food Research Institute (KFRI)funded by the Ministry of Science and ICT。

摘　　要：The prevalence of obesity has increased and is a health concern worldwide.Due to the concerns regarding synthetic anti-obesity treatments,nowadays natural products become a trend.Previous studies proved that there is a potential to use marine algae as anti-obesity agents.Therefore,in this study,the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii(STAC)and its fucoidan fractions(STAFs)on 3T3-L1 cells and high-fat diet(HFD)-induced obese mice were investigated.According to the results,the STAF3,showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 cells.Furthermore,oral supplementation with STAC significantly declined gain in body weight and fat weight,and serum lipid contents in an HFD-induced obesity mouse model.Structural and chemical characterizations demonstrated that puritied STAF3 has consistent surface morphology and small particle size,with similar structural characteristics as commercial fucoidan.Together,these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.

关 键 词：Sargassum thunbergii FUCOIDAN ANTI-OBESITY Anti-steatosis 

分 类 号：TS201.4[轻工技术与工程—食品科学]