酪蛋白胶束/聚乳酸静电纺丝复合纤维膜性质及其对黄芩苷的负载性能研究  

Properties of casein micelle/poly(lactic acid)electrospinning composite fiber membrane and its loading capacity for baicalin

作　　者：甄晨波 杨敏[1] 秦娟娟 郑杰 廖海周 魏彦明 ZHEN Chenbo;YANG Min;QIN Juanjuan;ZHENG Jie;LIAO Haizhou;WEI Yanming(College of Science,Gansu Agricultural University,Lanzhou 730070,China;College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]甘肃农业大学理学院,甘肃兰州730070 [2]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《食品与发酵工业》2024年第1期98-104,共7页Food and Fermentation Industries

基　　金：国家自然科学基金项目(32060812);国家现代农业产业技术体系项目(CARS-37);甘肃省高校产业支撑项目(2020C-14);甘肃省自然科学基金项目(22JR5RA861)。

摘　　要：黄芩苷是一种黄酮类化合物,具有抗炎、抑菌、抗病毒等多种药理作用,但其水溶性差,生物利用度低。为了改善黄芩苷的水溶性,该文利用静电纺丝技术制备负载黄芩苷的酪蛋白胶束/聚乳酸复合纤维膜,研究了其微观结构、疏水性、溶解特性和体外释放性等。结果显示,黄芩苷的添加对纤维微观结构影响不大。随着酪蛋白胶束添加比例的增加,纤维直径减小,成纤性能下降,当其与聚乳酸质量比达到2∶1时,纤维直径最小,成纤能力较好。红外光谱和X射线衍射结果分析表明,黄芩苷被包封在纤维内部。酪蛋白胶束改善了聚乳酸纤维膜的溶胀性和降解率。随着酪蛋白胶束添加量的增加,纤维膜亲水性增强,降解率增大,溶胀率减小,溶胀时间缩短。体外释放结果表明,酪蛋白胶束-聚乳酸纤维膜对黄芩苷有良好的控释效果。研究结果可为黄芩苷的负载提供参考依据。Baicalin is a kind of flavonoids,which has anti-inflammatory,antibacterial,antiviral,and other pharmacological effects,but it has poor water solubility and low bioavailability.To improve the water solubility of baicalin,a casein micelle/poly(lactic acid)composite fiber membrane loaded with baicalin was prepared by electrospinning technology.The microstructure,hydrophobicity,solubility,and in vitro release of baicalin were studied.Results showed that baicalin had little effect on the microstructure of the fibers.With the increase in the ratio of casein micelles,the fiber diameter decreased and the fiber-forming performance decreased.When the mass ratio of casein micelles to poly(lactic acid)reached 2∶1,the fiber diameter was the smallest and the fiber-forming ability was better.The results of infrared spectroscopy and X-ray diffraction showed that baicalin was encapsulated in the fibers.Moreover,casein micelles improved the swelling and degradation rate of poly(lactic acid)fiber membranes.With the increase of casein micelles,the hydrophilicity and degradation rate of the membrane were enhanced,and the swelling rate and swelling time were reduced.In vitro release results showed that the casein micelle-poly(lactic acid)fiber membrane had a good controlled release effect on baicalin.The results can provide a reference for the load of baicalin.

关 键 词：静电纺丝 黄芩苷 聚乳酸 酪蛋白胶束 复合纤维膜 

分 类 号：TS201.2[轻工技术与工程—食品科学] TQ340.64[轻工技术与工程—食品科学与工程]