Caspase家族与失神经支配骨骼肌萎缩的研究进展  

Research advances in the Caspase family and denervated skeletal muscle atrophy

作　　者：田淼 陈雨[2] 陶朋(综述) 陈沛(审校) TIAN Miao;CHEN Yu;TAO Peng(The First Clinical School of Hubei University of Chinese Medicine,Wuhan 430061,China)

机构地区：[1]湖北中医药大学第一临床学院,湖北武汉430061 [2]湖北中医药大学附属武汉市中西医结合医院,湖北武汉430000

出　　处：《中风与神经疾病杂志》2024年第1期84-87,共4页Journal of Apoplexy and Nervous Diseases

基　　金：湖北省卫生健康委面上项目(WJ2017M179);武汉市科学技术局应用基础前沿项目(2020020601012310)。

摘　　要：Caspase家族是含半胱氨酸的天冬氨酸蛋白水解酶的简称,根据主要作用分类可分为炎症Caspases和凋亡Caspases。在失神经支配骨骼肌萎缩中Caspases已被证实通过多种途径促进肌细胞凋亡。近年来有研究发现失神经支配肌细胞萎缩中Caspase-1所主导的细胞焦亡途径被激活,这是既往研究未提及的新的探索方向。现对Caspase家族在失神经支配骨骼肌萎缩中的作用进行概述。The Caspase family,short for cysteine-containing aspartate protein hydrolases,can be classified into inflammatory Caspases and apoptotic Caspases according to their role.It has been confirmed that Caspases promote myocyte apoptosis through multiple pathways in denervated skeletal muscle atrophy.In recent years,studies have shown that the pyroptosis pathway dominated by caspase-1 is activated in denervated myocyte atrophy,which is a new direction for exploration that is not mentioned in previous studies.This article reviews the role of the Caspase family in denervated skeletal muscle atrophy.

关 键 词：CASPASE家族 肌萎缩 失神经支配 

分 类 号：R746.4[医药卫生—神经病学与精神病学]