Harnessing nanobodies to expand the recognition spectrumof plant NLRs for diverse pathogens  

作　　者：Ruyi Wang Guo-Liang Wang Yuese Ning 

机构地区：[1]State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China [2]Department of Plant Pathology,The Ohio State University,Columbus,OH 43210,USA

出　　处：《aBIOTECH》2023年第3期272-276,共5页生物技术通报（英文版）

基　　金：supports from the National Natural Science Foundation of China(32001858 and U20A2021)to R.W.;the National Key Research and Development Program(2022YFD1401400);National Natural Science Foundation of China(32161143009)to Y.N.

摘　　要：The strategy to expand the recognition spectrum of plant nucleotide-binding domain leucine-richrepeat (NLR) proteins by modifying their recognition sequences is generally limited and oftenunsuccessful. Kourelis et al. introduced a groundbreaking approach for generating a customizedimmune receptor, called Pikobody. This method involves integrating a nanobody domain of a fluorescent protein (FP) into a plant NLR. Their research demonstrates that the resulting Pikobody successfully initiates an immune response against diverse pathogens when exposed to the corresponding FP.

关 键 词：NLR Pik NANOBODY Fluorescent protein IMMUNITY 

分 类 号：S432[农业科学—植物病理学]