基于硼亲和策略的纸基分子印迹膜对沙丁胺醇选择性吸附研究  

Selective Adsorption of Salbutamol on Paper-Based Molecularly Imprinted Membranes Based on Boron-Affinity Strategy

作　　者：周颖[1] 王鼎南 王扬 叶素丹[3] 王东辉 武斌[1] 张宜明[1] ZHOU Ying;WANG Dingnan;WANG Yang;YE Sudan;WANG Donghui;WU Bin;ZHANG Yiming(College of Food and Health,Zhejiang A&F University,Hangzhou,Zhejiang 311300;Institute of Zhejiang Aquatic Product Technology,Hangzhou,Zhejiang 310023;Zhejiang Institute of Economics and Trade,Hangzhou,Zhejiang 310018)

机构地区：[1]浙江农林大学食品与健康学院,浙江杭州311300 [2]浙江省水产推广技术总站,浙江杭州310023 [3]浙江经贸职业技术学院,浙江杭州310018

出　　处：《核农学报》2023年第12期2424-2433,共10页Journal of Nuclear Agricultural Sciences

基　　金：浙江省公益技术研究计划/分析测试项目(LGC20BO50007);浙江省“三农九方”科技协作计划项目(2023SNJF069);浙江省“领雁”研发攻关计划项目(2022C02G1323086)。

摘　　要：为探索建立一种从动物源性食品复杂基质中选择性分离富集沙丁胺醇(SAL)的方法,基于硼亲和与定向表面印迹策略,本研究以二氧化硅改性滤纸为基材成功制备了硼亲和纸基分子印迹吸附膜(FSM-BA@MIP)。采用扫描电镜(SEM)、X射线衍射(XRD)、傅里叶红外光谱(FTIR)和热重量分析(TGA)等多种技术手段进行了表征分析,并系统考察了吸附性能。结果表明,由于硼亲和定向表面印迹机制,所构筑的吸附膜FSM-BA@MIP对SAL具有高度选择性,理论最大吸附容量可达246.31 mg·g^(-1),印迹因子为3.2。吸附过程符合准二级动力学模型,以化学吸附为主,吸附等温线符合Freundlich模型,并伴随多层吸附。此外,再生试验结果表明,FSM-BA@MIP循环使用5次后仍能保持较好的吸附性能。对实际样品进行分析,回收率为65.7%~85.9%[平均相对标准偏差(RSD)为8.7%],最大富集倍数为87。本研究为发展新型食品中兽药残留选择性分离富集材料和策略提供了参考依据。To develop methods for the selective separation and enrichment of salbutamol(SAL)from complex matrices of animal-derived foods,FSM-BA@MIP was successfully prepared with silica-modified filter paper as the substrate based on the boron-affinity and directed surface imprinting strategy.Technologies including scanning electron microscope(SEM),X-ray diffraction(XRD),Fourier infrared transform spectroscopy(FTIR)and Thermogravimetric(TG)were adopted to characterize and analyze the FSM-BA@MIP,and systematically examine its adsorption properties.The results indicate that the constructed FSM-BA@MIP was highly selective for SAL due to the boron-affinity directed surface imprinting mechanism,with a theoretical maximum adsorption capacity of 246.31 mg·g^(-1) and an imprinting factor of 3.2.The adsorption process is largely chemisorption and in accordance with the pseudo-second order kinetic model.The adsorption isotherm conforms to the Freundlich model,and is accompanied by multilayer adsorption.The results of regeneration tests showed that FSM-BA@MIP could still maintain relatively good adsorption performance after recycled 5 times.The actual samples were analyzed,which indicated that recoveries ranged from 65.7%to 85.9%[average RSD(relative standard deviation)8.7%]and the maximum enrichment multiple was 87.This study provides reference for new materials and strategies for selective separation and enrichment of veterinary drug residues in food.

关 键 词：硼亲和 金属有机框架 分子印迹聚合物 吸附 沙丁胺醇 

分 类 号：TS207.53[轻工技术与工程—食品科学] O647.3[轻工技术与工程—食品科学与工程]