肝线粒体功能障碍在非酒精性脂肪性肝病发病中的作用机制  

The mechanism of action of mitochondrial dysfunction in the development of non-alcoholic fatty liver disease

作　　者：杨冰清 尹静亚 王琦[1] YANG Bingqing;YIN Jingya;WANG Qi(Center of Liver Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院肝病中心,北京100015

出　　处：《临床肝胆病杂志》2024年第1期147-150,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(82170591)。

摘　　要：非酒精性脂肪性肝病(NAFLD)逐渐成为影响人类肝脏健康的主要原因,其发生发展涉及多方面因素。线粒体作为细胞的“能量工厂”,对维持机体正常生理功能起着重要作用。研究表明,肝线粒体功能障碍促进NAFLD的发生发展。本文简要介绍了肝线粒体的基本特征和生理功能研究的新进展,综述了近年来线粒体功能障碍与肥胖、单纯性脂肪肝和非酒精性脂肪性肝炎关系研究方面的新成果,旨在为靶向线粒体治疗NAFLD提供研究思路。Nonalcoholic fatty liver disease(NAFLD)has gradually become the main reason affecting human liver health,and many factors are involved in the development and progression of NAFLD.Mitochondria,as the“energy factory”of cells,plays an important role in maintaining normal physiological functions.Studies have shown that hepatic mitochondrial dysfunction promotes the development and progression of NAFLD.This article briefly introduces the latest research advances in the basic characteristics and physiological function of liver mitochondria and reviews new research findings in the association of mitochondrial dysfunction with obesity,simple fatty liver disease,and nonalcoholic steatohepatitis,in order to provide new ideas for the research on targeted mitochondrial therapy for NAFLD.

关 键 词：非酒精性脂肪性肝病 线粒体 肝 氧化磷酸化 线粒体疾病 

分 类 号：R575.5[医药卫生—消化系统]