高频重复经颅磁刺激对首发青少年抑郁症患者认知功能、冷执行功能及自杀意念的影响  

Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Cognitive Function,Cold Executive Function,and Suicidal Ideation in First-Episode Adolescent Depression Patients

作　　者：侯春婷 杨震 朱荣鑫[1] 刘娟[1] 季金杰[1] 赵威威 HOU Chun-ting;YANG Zhen;ZHU Rong-xin;LIU Juan;JI Jin-jie;ZHAO Wei-wei(Department of Early Intervention Unit,Affiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangshu,210029,China)

机构地区：[1]南京医科大学附属脑科医院早期干预科,江苏南京210029

出　　处：《现代生物医学进展》2023年第23期4459-4462,4505,共5页Progress in Modern Biomedicine

基　　金：江苏省卫生与健康委员会医学重点项目(ZD2021026)。

摘　　要：目的:探讨高频重复经颅磁刺激(r TMS)对首发青少年抑郁症患者认知功能、冷执行功能及自杀意念的影响。方法:按照双色球法,将2020年10月~2022年11月期间南京医科大学附属脑科医院收治的114例首发青少年抑郁症患者分为对照组(富马酸喹硫平缓释片联合碳酸锂缓释片治疗,n=57)和观察组(对照组的基础上接受高频r TMS治疗,n=57)。对比两组临床疗效、抑郁症状、认知功能、冷执行功能、自杀意念和不良反应发生情况。结果:观察组的临床总有效率高于对照组(P<0.05)。两组治疗2周后、治疗4周后汉密尔顿抑郁量表-17(HAMD-17)评分下降,且观察组低于对照组同时间点(P<0.05)。两组治疗4周后蒙特利尔认知评估量表(MoCA)、听觉商数、注意力商数、视觉商数评分升高,且观察组高于对照组同时间点(P<0.05);贝克自杀意念量表中文版评分(BSI-CV)下降,且观察组低于对照组(P<0.05)。两组不良反应总发生率组间对比未见明显差异(P>0.05)。结论:高频r TMS治疗首发青少年抑郁症患者,可有效改善患者的认知功能、冷执行功能,降低自杀意念,进一步缓解临床症状,安全性较好。Objective:To explore the effects of high-frequency repetitive transcranial magnetic stimulation(rTMS)on cognitive function,cold executive function,and suicidal ideation in first-episode adolescent depression patients.Methods:According to the double color ball method,114 first-episode adolescent depression patients admitted to the Brain Hospital affiliated to Nanjing Medical University from October 2020 to November 2022 were divided into the control group(treated with Quetiapine Fumarate Extended-Release Tablets and Lithium Carbonate Sustained-release Tablets,n=57)and the observation group(treated with high-frequency rTMS on the basis of the control group,n=57).Control group received quetiapine fumarate combined with lithium carbonate treatment,and observation group received high-frequency rTMS treatment on the basis of control group.The clinical efficacy,depression symptoms,cognitive function,cold executive function,suicidal ideation,and incidence of adverse reactions were compared between two groups.Results:The clinical total effective rate in observation group was higher than that in control group(P<0.05).The Hamilton depression scale-17(HAMD-17)scores decreased in two groups 2 weeks after treatment and 4 weeks after treatment,and observation group was lower than that in control group at the same time point(P<0.05).The scores of Montreal cognitive assessment(MoCA),auditory quotient,attention quotient and visual quotient increased 4 weeks after treatment in two groups,and observation group were lower than those in control group at the same time point(P<0.05).The Chinese version of the Beck suicide intention scale(BSI-CV)scores decreased,and observation group was lower than that in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion:High-frequency rTMS treatment in first-episode adolescent depression patients,which can effectively improve patients'cognitive function,cold executive function,and reduce suicidal ideation,further

关 键 词：重复经颅磁刺激 抑郁症 青少年 冷执行功能 认知功能 自杀意念 

分 类 号：R749[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学] Q64[生物学—生物物理学]