GPX4相关的中枢神经系统疾病及其治疗进展  

GPX4-related central nervous system disease and its treatment progress

作　　者：蔡文慧 马凌云 霍丽蓉[1] CAI Wenhui;MA Lingyun;HUO Lirong(Central Laboratory,Fu Xing Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属复兴医院中心实验室,北京100038

出　　处：《中国医药科学》2023年第24期26-29,86,共5页China Medicine And Pharmacy

基　　金：北京市西城区优秀人才拔尖团队项目(201915);首都医科大学“本科生科研创新”项目(XSKY2022316)。

摘　　要：中枢神经系统(CNS)是人体神经系统的主体部分,是人体中结构和功能最精细、最复杂的系统。正因CNS的结构基础而造成了CNS疾病的多样化,发病机制深奥且复杂。构成CNS的基本单位是神经细胞,其受到损伤甚至死亡是许多CNS疾病发病的根本机制。铁死亡是近年来发现的一种细胞死亡途径,神经细胞的铁死亡在较多CNS疾病的发病过程中发挥重要作用。谷胱甘肽过氧化物酶4(GPX4)作为铁死亡调节通路中的关键酶更是成为了许多CNS疾病治疗研究的重要靶点。因此,本文着重阐述铁死亡中GPX4调节的关键机制,以及近年来与GPX4相关的CNS疾病治疗的研究进展,希望为今后CNS疾病治疗的相关研究提供方向。The central nervous system(CNS)is the main part of the human nervous system and is the most refined and complex system in terms of structure and function in the human body.Owing to the structural foundation of CNS,CNS diseases are diversified,and the pathogenesis is profound and complex.The basic unit that constitutes CNS is nerve cells,and the dam age or even death of cells is the fundamental mechanism of many CNS diseases.Ferroptosis is a cell death pathway discovered in recent years,and ferroptosis of nerve cells plays an important role in the pathogenesis of many CNS diseases.Glutathione peroxidase 4(GPX4),as a critical enzyme in the regulatory pathway of ferroptosis,has become an important target of many CNS disease treatment researches.Therefore,this article focuses on the critical mechanism of GPX4 regulation in ferroptosis and the research progress in the treatment of CNS diseases related to GPX4 in recent years,hoping to provide directions for future research on CNS disease treatment.

关 键 词：谷胱甘肽过氧化物酶4 铁死亡 中枢神经系统疾病 治疗 

分 类 号：R741[医药卫生—神经病学与精神病学]