海洋特征天然产物——硝基苯酯倍半萜类的研究进展  

Research progress of nitrobenzoyl sesquiterpenoids as marine characteristic natural products

作　　者：陈仪 佘江链 唐斓[3] 刘永宏[1,2] 周雪峰 CHEN Yi;SHE Jiang-lian;TANG Lan;LIU Yong-hong;ZHOU Xue-feng(CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China;University of Chinese Academy of Sciences,Beijing 100049,China;School of Pharmaceutical Sciences,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]中国科学院南海海洋研究所,中国科学院热带海洋生物资源与生态重点实验室,广东省海洋药物重点实验室,广东广州510301 [2]中国科学院大学,北京100049 [3]南方医科大学药学院,广东广州510515

出　　处：《药学学报》2024年第1期35-42,共8页Acta Pharmaceutica Sinica

基　　金：“广东特支计划”本土创新创业团队(2019BT02Y262);国家自然科学基金资助项目(U20A20101,81973235)。

摘　　要：倍半萜类化合物在自然界中广泛存在,而硝基苯酯倍半萜类化合物较为罕见。迄今发现的12种天然来源硝基苯酯倍半萜均来自于海洋曲霉属Aspergillus真菌,是一类典型的海洋特征天然产物。该类天然产物显示了较好的抗肿瘤、抗病毒和抑制破骨细胞分化活性,特别是在治疗破骨细胞相关疾病中显示较好的药用开发价值。本文对硝基苯酯倍半萜的天然产物来源和化学结构、化学和生物合成、生物活性和药理机制进行了综述,并对其吸收(absorption)、分布(distribution)、代谢(metabolism)、排泄(excretion)及毒性(toxicity)(ADME/T)和类药性进行预测和讨论,为海洋来源硝基苯酯倍半萜类天然产物及其药用开发潜力提供较为全面的认识。Sesquiterpenoids are widely found in nature,while nitrobenzoyl sesquiterpenoids are relatively rare.Twelve natural nitrobenzoyl sesquiterpenoids were all derived from marine Aspergillus fungi,which are typical natural products with marine characteristics.These natural products exhibit good antitumor,antiviral,and inhibition of osteoclast differentiation activity,especially in the treatment of osteoclast-related diseases,showing good medicinal development value.This article reviews the natural product sources,chemical structure,chemical synthesis,biosynthesis,bioactivity,and pharmacological mechanisms of nitrobenzoyl sesquiterpenoids and predicts and discusses their absorption,distribution,metabolism,excretion,toxicity(ADME/T),and drug-likeness,providing a comprehensive understanding of the natural products of nitrobenzoyl sesquiterpenoids from marine sources and their potential for pharmaceutical development.

关 键 词：硝基苯酯倍半萜 海洋天然产物 曲霉属 抑制破骨细胞分化 类药性 

分 类 号：R914[医药卫生—药物化学]