Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation  

作　　者：Amit Sharma Ingo G.H.Schmidt-Wolf 

机构地区：[1]Department of Integrated Oncology,Center for Integrated Oncology(CIO)Bonn,University Hospital Bonn,Bonn,Germany

出　　处：《Cellular & Molecular Immunology》2023年第12期1401-1402,共2页中国免疫学杂志（英文版）

摘　　要：Although cancer immunotherapy has taken center stage,exhaustion of T cells is undeniably one of the major problems preventing it from being fully successful[1].Certainly,reversal of T-cell exhaustion or dysfunction is of great importance for developing new strategies and restoring immune function.Nevertheless,counterarguments about the adverse effect of reversing T-cell exhaustion(leading to overactivation of T cells and cytotoxicity)and even their irreversible properties have been quite common in scientific debates.With more to be discovered about the reasons for T-cell failure,a better understanding of the molecular factors/determinants[2,3]that shape/remodel“heterogeneous”dysfunctional T cells in cancer makes clear sense.Indeed,two recent publications in Nature immunology have described the intriguing perspective of T-cell exhaustion[4,5].Of interest,Vignali et al.focused on the hypoxia-driven CD39-dependent suppressor function of exhausted T cells,whereas Saadey et al.emphasized restoring the epigenetic balance of TGFβ1/BMP signaling in exhausted T cells to unlock responsiveness to immune checkpoint blockade therapy.

关 键 词：IRREVERSIBLE EXHAUSTION PUBLICATIONS 

分 类 号：R73[医药卫生—肿瘤] Q25[医药卫生—临床医学]