EXHAUSTION

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No more LAGging behind PD-1:uncovering the unique role of LAG-3 in T-cell exhaustion
《Cellular & Molecular Immunology》2024年第12期1351-1353,共3页Yunju Jo Hyung-seung Jin Yoon Park 
supported by an intramural grant from KIST to YP,as well as grants from the National Research Foundation of Korea(NRF)funded by the Korean government(MSIT)(NRF-2020M3A9G7103935 and RS-2024-00338729 to HJ and RS-2024-00337093 to YP).
Exhausted T(Tex)cells are a distinct subset of T cells that arise in response to prolonged antigen exposure during chronic infections or cancer.Although Tex cells exhibit reduced functionality,they still retain some p...
关键词：IMMUNITY protective thereby 
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
《Military Medical Research》2024年第6期863-886,共24页Dian Xiong Lu Zhang Zhi-Jun Sun 
supported by the National Natural Science Foundation of China(82273202,82370948,82072996,82170941);the Fundamental Research Funds for the Central Universities(2042022dx0003);the Hubei Province International Science and Technology Cooperation Project(2021EHB027);the National Key Research and Development Program(2022YFC2504200).
Cancer immunotherapy using immune-checkpoint inhibitors(ICIs)has revolutionized the field of cancer treatment;however,ICI efficacy is constrained by progressive dysfunction of CD8+tumor-infiltrating lymphocytes(TILs),...
关键词：Epigenetic therapy Immune checkpoint blockade Combination therapy T cell exhaustion Immune macroenvironment Spatial immune contexture Immunometabolism Cancer microbiome 
Myeloid cells meet CD8^(+)T cell exhaustion in cancer:What,why and how
《Chinese Journal of Cancer Research》2024年第6期616-651,共36页Yijie Zhai Xiaoting Liang Mi Deng 
supported by grants from the National Key Research and Development Program of China(No.2022YFA1304504);National Natural Science Foundation of China(No.82293633 and 82270180)。
Exhausted T cell(Tex)is a specific state of T cell dysfunction,in which these T cells gradually lose their effector function and change their phenotype during chronic antigen stimulation.The enrichment of exhausted CD...
关键词：CANCER CD8^(+)T cell exhaustion myeloid cells reinvigorate T cellexhaustion IMMUNOTHERAPY 
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
《Signal Transduction and Targeted Therapy》2024年第11期5267-5285,共19页Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han Huarui Fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu Pengxu Qian He Huang 
supported by the National Key Research and Development Program of China(2022YFA1103500 to P.Q.);the National Key Nature Science Foundation of China(82130003 to H.H.);the Key Project of Science and Technology Department of Zhejiang Province(2019C03016 and 2020C03G2013586 to H.H.,Z24H080001 to P.Q.);the National Natural Science Foundation of China(82200248 and 82000194 to H.H.,82222003 and 82161138028 to P.Q.);the Key R&D Program of Zhejiang(2024SSYS0023 to H.H.,2024SSYS0024 to P.Q.,2024SSYS0025 to Y.H.);the Fundamental Research Funds for the Central Universities(226-2024-00007 to P.Q.).
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)cells.MEK1/2 inhibitors(MEKIs),widely...
关键词：JUNB metabolism STIMULATION 
Local TSH/TSHR signaling promotes CD8^(+) T cell exhaustion and immune evasion in colorectal carcinoma
《Cancer Communications》2024年第11期1287-1310,共24页Sisi Zeng Huiling Hu Zhiyang Li Qi Hu Rong Shen Mingzhou Li Yunshi Liang Zuokang Mao Yandong Zhang Wanqi Zhan Qin Zhu Feifei Wang Jianbiao Xiao Bohan Xu Guanglong Liu Yanan Wang Bingsong Li Shaowan Xu Zhaowen Zhang Ceng Zhang Zhizhang Wang Li Liang 
supported by the National Key R&D Program of China(Grant No.2021YFF1201004);the National Natural Science Foundation of China(Grant No.82273358,No.81802306,No.81903002,No.81672821,No.82071742,No.32270926);Natural Science Foundation of Guangdong Province of China(Grant No.2019A1515012196,No.2022A1515012059).
Dysfunction of CD8^(+)T cells in the tumor microenvironment(TME)contributes to tumor immune escape and immunotherapy tolerance.The effects of hormones such as leptin,steroid hormones,and glucocorticoids on T cell func...
关键词：Thyroid stimulating hormone Thyroid stimulating hormone receptor Colorectal carcinoma T cell exhaustion Immune evasion 
Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4+T cells
《Cellular & Molecular Immunology》2024年第11期1296-1308,共13页Shuai Wang Lijun Meng Nan Xu Huan Chen Zhaofeng Xiao Di Lu Xiaohui Fan Limin Xia Jun Chen Shusen Zheng Qiang Wei Xuyong Wei Xiao Xu 
supported by the Key Program,National Natural Science Foundation of China(No.81930016);National Key Research and Development Program of China(No.2021YFA1100500);Key Research&Development Plan of Zhejiang Province(No.2019C03050);Construction Fund of Key Medical Disciplines of Hangzhou(OO20200093);Key Research&Development Plan of Zhejiang Province(No.2021C03118),Projects of Medical and Health Technology Program in Zhejiang Province(WKJ-ZJ-2120);National Natural Science Foundation of China(No.82273177,No.12304256);Natural Science Foundation of Zhejiang Province(LY22H160046,LQ24C050005);Key Research and Development Plan of Zhejiang Province(2022C03108).Joint Funds of the National Natural Science Foundation of China(No.U23A20451).
Hepatocellular carcinoma(HCC)is a highly malignant tumor with significant global health implications.The role of CD4+T cells,particularly conventional CD4+T cells(Tconvs),in HCC progression remains unexplored.Furtherm...
关键词：MATR3 Tconv ARID1A TOX EXHAUSTION 
PD-1 and LAG-3:synergistic fostering of T cell exhaustion
《Signal Transduction and Targeted Therapy》2024年第11期4779-4780,共2页Maike Hofmann Robert Thimme Wolfgang W.Schamel 
supported by the DFG under Germany’s Excellence Strategy-EXC-2189-Project ID:390939984;under the Excellence Initiative of the German Federal and State Governments-EXC-294;in part by the Ministry for Science,Research and Arts of the State of Baden-Württemberg;Further support is given by the German Research Foundation(DFG)under FOR2799(SCHA976/8-2 to W.W.S.);CRC1381(Project ID:403222702-A9 to W.W.S.);CRC1160(Project ID:256073931-A02 to R.T.and M.H.);TRR179(Project ID:272983813-TP01 to R.T.and TP20 to M.H.);CRC1479(Project ID:441891347-P10 to M.H.);M.H.is supported by the Heisenberg program of the German Research Foundation.
In the August issue of Cell 2024,three back-to-back papers disentangled non-redundant inhibitory mechanisms of PD-1 and LAG-3 in exhausted murine and human CD8+T cells.^(1-3) These findings will have a clear impact on...
关键词：SYNERGISTIC REDUNDANT finding 
Intracellular checkpoints for NK cell cancer immunotherapy
《Frontiers of Medicine》2024年第5期763-777,共15页Yingying Huang Zhigang Tian Jiacheng Bi 
supported by the National Key R&D Program of China(No.2020YFA0710802 to Jiacheng Bi);Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110174 to Yingying Huang);the National Natural Science Foundation of China(No.82071768 to Jiacheng Bi).
Natural killer(NK)cells are key innate immune lymphocytes,which play important roles against tumors.However,tumor-infiltrating NK cells are always hypofunctional/exhaustive.On the one hand,this state is contributed by...
关键词：genomic editing NK cell exhaustion immune checkpoint inhibitory molecules immune tolerance 
New perspective on the treatment of rheumatic arthritis based on“strengthening body resistance(Fú Zhèng)”in the theory of co-inhibitory receptor-regulated T-cell immunity
《Acupuncture and Herbal Medicine》2024年第3期290-294,共5页Yifei Xu Linda Zhong Qianqian Liang Hao Xu 
supported by the National Innovation and Entrepreneurship Training Program for College Students(202310268058);Exploration of the Mechanism on Therapeutic Efficacy of Gulong Capsules in Treatment of Osteoarthritis from the Perspective of Multi-omics(E4-H23066).
Co-inhibitory receptors serve as crucial regulators of T-cell function,playing a pivotal role in modulating the delicate balance between immune tolerance and autoimmunity.Initially identified in autoimmune disease mod...
关键词：Combination of Chinese and Western Medicine Co-inhibitory receptors Rheumatic arthritis T-cell exhaustion 
Unlocking T cell exhaustion:Insights and implications for CAR-T cell therapy
《Acta Pharmaceutica Sinica B》2024年第8期3416-3431,共16页Dian Xiong Haijun Yu Zhi-Jun Sun 
supported by National Natural Science Foundation of China(Nos.82273202,82072996,82073349);National Key Research and Development Program(No.2022YFC2504200,China);Fundamental Research Funds for the Central Universities(No.2042024kf0021,China);Interdisciplinary Innovative Foundation of Wuhan University(No.XNJC202303,China).
Chimeric antigen receptor T(CAR-T)cell therapy as a form of adoptive cell therapy(ACT)has shown significant promise in cancer treatment,demonstrated by the FDA-approved CAR-T cell therapies targeting CD19 or B cell ma...
关键词：Cancer immunotherapy CAR-T therapy T cell exhaustion Tumor immune microenvironment Spatial immune contexture Single-cell technologies CAR-T engineering Combination therapy 
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