Myeloid cells meet CD8^(+)T cell exhaustion in cancer:What,why and how  

作　　者：Yijie Zhai Xiaoting Liang Mi Deng 

机构地区：[1]School of Basic Medical Sciences,Health Science Center,Peking University,Beijing 100191,China [2]State Key Laboratory of Molecular Oncology,Peking University International Cancer Institute,Health Science Center,Peking University,Beijing 100191,China [3]Peking University Cancer Hospital&Institute,Beijing 100142,China

出　　处：《Chinese Journal of Cancer Research》2024年第6期616-651,共36页中国癌症研究(英文版)

基　　金：supported by grants from the National Key Research and Development Program of China(No.2022YFA1304504);National Natural Science Foundation of China(No.82293633 and 82270180)。

摘　　要：Exhausted T cell(Tex)is a specific state of T cell dysfunction,in which these T cells gradually lose their effector function and change their phenotype during chronic antigen stimulation.The enrichment of exhausted CD8^(+)T cell(CD8^(+)Tex)in the tumor microenvironment is one of the important reasons leading to the poor efficacy of immunotherapy.Recent studies have reported many reasons leading to the CD8^(+)T cell exhaustion.In addition to cancer cells,myeloid cells can also contribute to T cell exhaustion via many ways.In this review,we discuss the history of the concept of exhaustion,CD8^(+)T cell dysfunction states,the heterogeneity,origin,and characteristics of CD8^(+)Tex.We then focus on the effects of myeloid cells on CD8^(+)Tex,including tumor-associated macrophages(TAMs),dendritic cells(DCs)and neutrophils.Finally,we systematically summarize current strategies and recent advancements in therapies reversing and CD8^(+)T cell exhaustion.

关 键 词：CANCER CD8^(+)T cell exhaustion myeloid cells reinvigorate T cellexhaustion IMMUNOTHERAPY 

分 类 号：R73[医药卫生—肿瘤]