Dual inhibition of PD-1 and LAG-3:uncovering mechanisms to reverse T cell exhaustion and enhance anti-tumor immunity  

PD-1和LAG-3的双重抑制逆转T细胞耗竭并增强抗肿瘤免疫的机制

作　　者：Xiaoxue Zhou Fangfang Zhou Long Zhang 周晓雪;周芳芳;张龙

机构地区：[1]School of Medicine,Hangzhou City University,Hangzhou 310015,China [2]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310058,China [3]The First Affiliated Hospital,the Institutes of Biology and Medical Sciences,Suzhou Medical College,Soochow University,Suzhou 215031,China [4]MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou 310058,China [5]The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330031,China [6]Cancer Center,Zhejiang University,Hangzhou 310058,China

出　　处：《Science Bulletin》2025年第5期624-626,共3页科学通报(英文版)

基　　金：National Natural Science Foundation of China(31925013,32125016,T2321005 and W2411011);National Key Research and Development Program of China(2021YFA1101000,2022YFA1105200 and 2023YFA1800200);Key R&D Program of Zhejiang Province(2024C03142);Joint Project of Pinnacle Disciplinary Group,the Second Affiliated Hospital of Chongqing Medical,the Science Foundation of Jiangsu Province(19KJA550003);Suzhou Innovation and Entrepreneurship Leading Talent Program(ZXL2022505);Suzhou Medical College Basic Frontier Innovation Cross Project(YXY2303027);Key Cross-research Projects of the School of Medicine,Soochow University(YXY2303027);support of Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases.

摘　　要：Recent studies published in Cell have elucidated the collaborative roles of LAG-3 and PD-1 in driving T cell exhaustion,revealing how targeting both immune checkpoints could enhance immune responses[1],[2],[3].Among these,two studies were led by Dario A.A.Vignali's team at the University of Pittsburgh School of Medicine,while the third was conducted by E.John Wherry's team at the University of Pennsylvania.

关 键 词：IMMUNITY driving EXHAUSTION 

分 类 号：R73[医药卫生—肿瘤]