The role of cellular and molecular neuroimmune crosstalk in gut immunity  

作　　者：Daping Yang Nicole Almanzar Isaac M.Chiu 

机构地区：[1]Department of Immunology,Harvard Medical School,Boston,MA,02115,USA

出　　处：《Cellular & Molecular Immunology》2023年第11期1259-1269,共11页中国免疫学杂志（英文版）

基　　金：The Chiu Lab is supported by NIH grants R01 DK127257 and R01 AI168005,Kenneth Rainin Foundation,Burroughs Wellcome Fund,Food Allergy Science Initiative,Chan-Zuckerberg Initiative,Fairbairn Lyme Initiative,Drako Family Foundation,and Jackson-Wijaya Research Fund.

摘　　要：The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system.These two systems critically coordinate the sensations of and adaptations to dietary,microbial,and damaging stimuli from the external and internal microenvironment during tissue homeostasis and inflammation.The brain receives and integrates ascending sensory signals from the gut and transduces descending signals back to the gut via autonomic neurons.Neurons regulate intestinal immune responses through the action of local axon reflexes or through neuronal circuits via the gut-brain axis.This neuroimmune crosstalk is critical for gut homeostatic maintenance and disease resolution.In this review,we discuss the roles of distinct types of gut-innervating neurons in the modulation of intestinal mucosal immunity.We will focus on the molecular mechanisms governing how different immune cells respond to neural signals in host defense and inflammation.We also discuss the therapeutic potential of strategies targeting neuroimmune crosstalk for intestinal diseases.

关 键 词：NEUROIMMUNOLOGY NEUROIMMUNE Host defense GUT SENSORY 

分 类 号：R392[医药卫生—免疫学]