Immunoception:the insular cortex perspective  

作　　者：Asya Rolls 

机构地区：[1]Department of Immunology,Department of Neuroscience,Technion,Israel Institute of Technology,Haifa,Israel

出　　处：《Cellular & Molecular Immunology》2023年第11期1270-1276,共7页中国免疫学杂志（英文版）

摘　　要：To define the systemic neuroimmune interactions in health and disease,we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system.This concept suggests that the brain constantly monitors changes in immune activity and,in turn,can regulate the immune system to generate a physiologically synchronized response.Therefore,the brain has to represent information regarding the state of the immune system,which can occure in multiple ways.One such representation is an immunengram,a trace that is partially stored by neurons and partially by the local tissue.This review will discuss our current understanding of immunoception and immunengrams,focusing on their manifestation in a specific brain region,the insular cortex(IC).

关 键 词：INFLAMMATION BRAIN SYMPATHETIC 

分 类 号：R392[医药卫生—免疫学]