马乳源性生物活性肽生物学信息及其抗肺癌作用靶点探索  

Biological information of equine milk-derived bioactive peptides and their anti-lung cancer targets

作　　者：古丽巴哈尔·卡吾力[1] 马建宝 卡丽比努尔·艾尔肯 徐志伟 高晓黎[1] Gulibahar Kawuli;MA Jianbao;Kalibinur Arken;XU Zhiwei;GAO Xiaoli(Xinjiang Medical University College of Pharmacy,Urumqi 830000,China)

机构地区：[1]新疆医科大学药学院,乌鲁木齐830000

出　　处：《中国乳品工业》2024年第1期17-21,64,共6页China Dairy Industry

基　　金：新疆维吾尔自治区重大科技专项(2022A02013-3-2)。

摘　　要：在前期研究基础上通过在线软件对已知氨基酸组成的马乳源性活性肽生物学信息和关键靶蛋白进行分析并进行分子对接,探索马乳源性活性肽抗肺癌作用靶点。结果表明马乳源的活性肽为不稳定、带正电荷的亲水性多肽,是没有跨膜区和信号肽,也没有糖基化和磷酸化位点的细胞膜外多肽,二级结构主要以无规则卷曲为主,与肺癌相关的核心靶点即CTNNB1、FGFR2、FOXF1、KRAS、NKX2-1、TGFBR2具有很好的结合亲和力,为深入研究马乳源活性肽的生物学功能奠定了基础。On the basis of the previous research,the biological information and key target proteins of horse milk-derived active peptides with known amino acid composition were analysed and molecularly docked by online software to explore the anti-lung cancer targets of horse milk-derived active peptides.The results showed that the active peptides derived from horse milk were unstable,positively charged hydrophilic polypeptides,with no transmembrane regions and signal peptides,no glycosylation and phosphorylation sites of extramembrane polypeptides,and the secondary structure was mainly irregular curling,and the core targets related to lung cancer,namely CTNNB1,FGFR2,FOXF1,KRAS,NKX2-1 and TGFBR2,had good binding affinity,which laid a foundation for in-depth study of the biological functions of horse milk-derived active peptides.

关 键 词：抗氧化肽 生物学信息 分子对接 肺癌 NKX2-1 CTNNB1 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]