Anti-aging activity and their mechanisms of natural food-derived peptides:current advancements  

作　　者：Jialong Li Jiaojiao Wang Ning Zhang Ying Li Zizhe Cai Guanghui Li Zhongbo Liu Zhiping Liu Yong Wang Xin Shao Jing Chen 

机构地区：[1]Guangdong Joint International Research Centre of Oilseed Biorefinery,Nutrition and Safety,Jinan University,Guangzhou,Guangdong 510632,China [2]Guangdong Engineering Technology Research Center for Cereal and Oil Byproduct Biorefinery,Jinan University,Guangzhou,Guangdong 510632,China [3]Guangdong Saskatchewan Oilseed Joint Laboratory,Department of Food Science and Engineering,Jinan University,Guangzhou,Guangdong 510632,China [4]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy,Jinan University,Guangzhou,Guangdong,510632 China [5]Institute for Advanced and Applied Chemical Synthesis,Jinan University,Guangzhou,Guangdong 510632,China

出　　处：《Food Innovation and Advances》2023年第4期272-290,共19页食品创新与进展（英文）

基　　金：supported by the National Key R&D Program of China(Grant No.2018YFE0108400);Guangzhou Science and Technology Plan Project(Grant No.201903010049)are gratefully acknowledged.

摘　　要：Recently,there has been a growing focus on researching ways to delay aging and protect against age-related illnesses.Small molecular exogenous peptides,sourced from dietary elements like animals,plants,and microorganisms,have demonstrated considerable potential in exerting anti-aging effects.Notably,natural food-derived peptides have exhibited enhanced stability,safety,absorption efficiency,and heightened biological activity.These attributes position them with a greater potential for mitigating aging-related disorders compared to alternative anti-aging drugs or phytochemicals.This review summarizes the origins,structural attributes,and isolation methods of natural foodderived peptides with anti-aging properties.It also explores how these external peptides improve aging-related conditions such as neurodegenerative diseases,skin aging,and metabolic disorders.The underlying mechanisms dictating their impact on well-conserved signaling pathways—encompassing oxidative stress,inflammation,apoptosis,and collagen synthesis—are meticulously elucidated.This paper engages in an insightful exploration of the key challenges and pivotal trajectories,grounded in ongoing research endeavors.As a result,this review is poised to offer authoritative scientific guidance and invaluable support for the practical implementation of natural food-derived peptides in the realm of anti-aging applications within the food,pharmaceutical,and cosmetic industries.

关 键 词：properties. OXIDATIVE AGING 

分 类 号：TS201[轻工技术与工程—食品科学]