Updates on management of gliomas in the molecular age  

作　　者：Ali Ahmed Mohamed Rakan Alshaibi Steven Faragalla Youssef Mohamed Brandon Lucke-Wold 

机构地区：[1]Charles E.Schmidt College of Medicine,Florida Atlantic University,Boca Raton,FL 33431,United States [2]Herbert Wertheim College of Medicine,Florida International University,Miami,FL 33199,United States [3]College of Osteopathic Medicine,Kansas City University,Joplin,MO 64804,United States [4]Department of Neurosurgery,University of Florida,Gainesville,FL 32611,United States

出　　处：《World Journal of Clinical Oncology》2024年第2期178-194,共17页世界临床肿瘤学杂志（英文版）

摘　　要：Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic challenges.Recent developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular lineage.This review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year 2023.For adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and radiotherapy.In contrast,pediatric gliomas,due to their diversity,require a more tailored approach.Although complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and carboplatin.Addi-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be used.Despite recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric cohorts.This review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关 键 词：GLIOMAS Chemotherapy RADIOTHERAPY Isocitrate dehydrogenase type mutant Pediatric gliomas ASTROCYTOMA OLIGODENDROGLIOMA 1p/19q-codeleted 

分 类 号：R737.9[医药卫生—肿瘤]