Deregulation of interferon-gamma receptor 1 expression and its implications for lung adenocarcinoma progression  

作　　者：Angeles C Tecalco-Cruz Karen H Medina-Abreu Enrique Oropeza-Martínez Jesus Zepeda-Cervantes AleidaVázquez-Macías Marina Macías-Silva 

机构地区：[1]Posgrado en Ciencias Genómicas,Universidad Autónoma de la Ciudad de México,CDMX 03100,Mexico [2]Facultad de Medicina Veterinaria y Zootecnia,Universidad Nacional Autónoma de México,CDMX 04510,Mexico [3]Colegio de Ciencias y Humanidades,Universidad Autónoma de la Ciudad de México,CDMX 03100,Mexico [4]Instituo de Fisiología Celular,Universidad Nacional Autónoma de México,CDMX 04510,Mexico

出　　处：《World Journal of Clinical Oncology》2024年第2期195-207,共13页世界临床肿瘤学杂志（英文版）

摘　　要：Interferon-gamma(IFN-γ)plays a dual role in cancer;it is both a pro-and an antitumorigenic cytokine,depending on the type of cancer.The deregulation of the IFN-γcanonic pathway is associated with several disorders,including vulner-ability to viral infections,inflammation,and cancer progression.In particular,the interplay between lung adenocarcinoma(LUAD)and viral infections appears to exist in association with the deregulation of IFN-γsignaling.In this mini-review,we investigated the status of the IFN-γsignaling pathway and the expression level of its components in LUAD.Interestingly,a reduction in IFNGR1 expression seems to be associated with LUAD progression,affecting defenses against viruses such as severe acute respiratory syndrome coronavirus 2.In addition,alterations in the expression of IFNGR1 may inhibit the antiproliferative action of IFN-γsignaling in LUAD.

关 键 词：INTERFERON-GAMMA IFNGR1 JAK1 ANTIVIRAL ANTI-TUMOR Lung adenocarcinoma 

分 类 号：R734.2[医药卫生—肿瘤]