Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer  

作　　者：Hongsik Kim Song-Yi Choi Tae-Young Heo Kyeong-Rok Kim Jisun Lee Min Young Yoo Taek-Gu Lee Joung-Ho Han 

机构地区：[1]Department of Internal Medicine,Chungbuk National University Hospital,Cheongju 28644,South Korea [2]Department of Pathology,Chungnam National University College of Medicine,Daejeon 35015,South Korea [3]Information and Statistics,Chungbuk National University,Cheongju 28644,South Korea [4]Department of Radiology,College of Medicine,Chungbuk National University,Chungbuk National University Hospital,Cheongju-si 28644,South Korea [5]Department of Nuclear Medicine,School of Medicine,Inha University,Incheon 22332,South Korea [6]Department of Surgery,Chungbuk National University,College of Medicine,Cheongju-si 28644,South Korea [7]Department of Internal Medicen,Chungbuk National University,College of medicine,Cheongju-si 28644,South Korea

出　　处：《World Journal of Clinical Cases》2024年第5期931-941,共11页世界临床病例杂志

摘　　要：BACKGROUND There are limited data on the use of glucose transport protein 1(GLUT-1)expre-ssion as a biomarker for predicting lymph node metastasis in patients with colorectal cancer.GLUT-1 and GLUT-3,hexokinase(HK)-II,and hypoxia-induced factor(HIF)-1 expressions may be useful biomarkers for detecting primary tumors and lymph node metastasis when combined with fluorodeoxyglucose(FDG)uptake on positron emission tomography/computed tomography(PET/CT).AIM To evaluate GLUT-1,GLUT-3,HK-II,and HIF-1 expressions as biomarkers for detecting primary tumors and lymph node metastasis with 18F-FDG-PET/CT.METHODS This retrospective study included 169 patients with colorectal cancer who underwent colectomy and preoperative 18F-FDG-PET/CT at Chungbuk National University Hospital between January 2009 and May 2012.Two tissue cores from the central and peripheral areas of the tumors were obtained and were examined by a dedicated pathologist,and the expressions of GLUT-1,GLUT-3,HK-II,and HIF-1 were determined using immunohisto-chemical staining.We analyzed the correlations among their expressions,various clinicopathological factors,and the maximum standardized uptake value(SUVmax)of PET/CT.RESULTS GLUT-1 was found at the center or periphery of the tumors in 109(64.5%)of the 169 patients.GLUT-1 positivity was significantly correlated with the SUVmax of the primary tumor and lymph nodes,regardless of the biopsy site(tumor center,P<0.001 and P=0.012;tumor periphery,P=0.030 and P=0.010,respectively).GLUT-1 positivity and negativity were associated with higher and lower sensitivities of PET/CT,respectively,for the detection of lymph node metastasis,regardless of the biopsy site.GLUT3,HK-II,and HIF-1 expressions were not significantly correlated with the SUVmax of the primary tumor and lymph nodes.CONCLUSION GLUT-1 expression was significantly correlated with the SUVmax of 18F-FDG-PET/CT for primary tumors and lymph nodes.Clinicians should consider GLUT-1 expression in preoperative endoscopic biopsy in interpreting PET/CT findings.

关 键 词：18F-FDG-PET-CT BIOMARKER Colorectal neoplasms Glucose transporter type 1 Lymph node 

分 类 号：R735.35[医药卫生—肿瘤]