整合素β3基因多态性蛋白质变异及其与疾病关系研究进展  

Research progress on protein variations of integrin β3 gene polymorphisms and their relationship with disease

作　　者：韦宝敏[1] 潘兴寿[1] 李近都 李天资[1] WEI Baomin;PAN Xingshou;LI Jindu;LI Tianzi(Department of Cardiology,Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi,Baise 533000,China;Department of Hepatobiliary,Pancreatic and Splenic Surgery,Guangxi Medical University Cancer Hospital,Guangxi,Nanning 530021,China)

机构地区：[1]右江民族医学院附属医院心血管内科,广西百色533000 [2]广西医科大学附属肿瘤医院肝胆胰脾外科,广西南宁530021

出　　处：《中国医药科学》2024年第1期42-46,共5页China Medicine And Pharmacy

基　　金：广西自然科学基金项目(2020GXNSFAA259062);广西壮族自治区百色市科学研究与技术开发计划(20222940;20230512)。

摘　　要：整合素(ITG)β3基因位于17号染色体长臂2区1号3带(17q21.3),基因区间在47253827~47313743,全长59917 kb,编码区间在47253862~47310204,全长56343 kb,有15个外显子、14个内含子;编码1648个氨基酸残基,分子量为105 kDa。ITGβ3蛋白是一种二价离子依赖性细胞黏附分子,广泛存在于细胞膜中。其主要功能是介导细胞之间,细胞和细胞外基质之间的识别、连接和黏附,主导细胞内外跨膜接头蛋白连接的作用。近年来,关于ITG在细胞识别与黏附、细胞活化与分化、免疫反应、细胞信号传导、炎症反应、创伤修复与愈合、凝血与血栓形成、肿瘤形成与转移等方面发挥重要作用的研究取得许多进展,本文综述如下。Integrin(ITG)β3 gene is located in chromosome 17,long arm,region 2,No.1,band 3(17q21.3).The gene interval is between 47253827-47313743,with a total length of 59917 kb.The coding range is 47253862-47310204,and the total length is 56343 kb,with 15 exons and 14 introns.It encodes 1648 amino acid residues and has a molecular weight of 105 kDa.Integrin β3 protein is a bivalent ion-dependent cell adhesion molecule widely present in cell membranes.Its main function is to mediate recognition,connection,and adhesion between cells,as well as between cells and extracellular matrix,leading to the role of intracellular and intracellular transmembrane adaptor protein connection.In recent years,integrin has played an important role in cell recognition and adhesion,cell activation and differentiation,immune response,cell signal transduction,inflammatory response,wound repair and healing,coagulation and thrombosis,tumor formation and metastasis,and many advances have been made,which are reviewed in this article.

关 键 词：整合素Β3 基因突变 糖基化修饰 细胞黏附分子 炎症反应 

分 类 号：R394[医药卫生—医学遗传学]