Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression  

作　　者：Ying Ma Yue Qiao Xiang Gao 

机构地区：[1]Spinal Cord and Brain Injury Research Group,Stark Neuroscience Research Institute,Indianapolis,IN,USA [2]Department of Neurological Surgery,Indiana University School of Medicine,Indianapolis,IN,USA [3]Department of Neurology,Shengjing Hospital of China Medical University,Shenyang,Liaoning Province,China

出　　处：《Neural Regeneration Research》2024年第10期2144-2156,共13页中国神经再生研究（英文版）

基　　金：supported by the Showalter Research Trust Fund (to XG);Indiana Spinal Cord&Brain Injury Research Fund (ISCBIRF) from the Indiana State Departm ent of Health (to XG)。

摘　　要：It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关 键 词：antidepressants chronic pain DEPRESSION EXERCISE hippocampal neurogenesis inflammation inhibition NEUROINFLAMMATION physical activity deficits social isolation spinal cord injury 

分 类 号：R651.2[医药卫生—外科学] R749.4[医药卫生—临床医学]