Unraveling the gut-brain axis:the impact of steroid hormones and nutrition on Parkinson's disease  

作　　者：Paula Maria Neufeld Ralf A.Nettersheim Veronika Matschke Matthias Vorgerd Sarah Stahlke Carsten Theiss 

机构地区：[1]Department of Cytology,Institute of Anatomy,Medical Faculty,Ruhr-University Bochum,Bochum,Germany [2]Department of Visceral Surgery,University Hospital Bergmannsheil,Ruhr-University Bochum,Bochum,Germany [3]Department of Neurology,Heimer Institute for Muscle Research,University Hospital Bergmannsheil,Ruhr-University Bochum,Bochum,Germany

出　　处：《Neural Regeneration Research》2024年第10期2219-2228,共10页中国神经再生研究（英文版）

摘　　要：This comprehensive review explores the intricate relationship between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the context of the gut-brain axis.The gut-brain axis plays a pivotal role in neurodegenerative diseases like Parkinson's disease,encompassing diverse components such as the gut microbiota,immune system,metabolism,and neural pathways.The gut microbiome,profoundly influenced by dietary factors,emerges as a key player.Nutrition during the first 1000 days of life shapes the gut microbiota composition,influencing immune responses and impacting both child development and adult health.High-fat,high-sugar diets can disrupt this delicate balance,contributing to inflammation and immune dysfunction.Exploring nutritional strategies,the Mediterranean diet's anti-inflammatory and antioxidant properties show promise in reducing Parkinson's disease risk.Microbiome-targeted dietary approaches and the ketogenic diet hold the potential in improving brain disorders.Beyond nutrition,emerging research uncovers potential interactions between steroid hormones,nutrition,and Parkinson's disease.Progesterone,with its anti-inflammatory properties and presence in the nervous system,offers a novel option for Parkinson's disease therapy.Its ability to enhance neuroprotection within the enteric nervous system presents exciting prospects.The review addresses the hypothesis thatα-synuclein aggregates originate from the gut and may enter the brain via the vagus nerve.Gastrointestinal symptoms preceding motor symptoms support this hypothesis.Dysfunctional gut-brain signaling during gut dysbiosis contributes to inflammation and neurotransmitter imbalances,emphasizing the potential of microbiota-based interventions.In summary,this review uncovers the complex web of interactions between nutrition,the gut microbiome,steroid hormones,and Parkinson's disease within the gut-brain axis framework.Understanding these connections not only offers novel therapeutic insights but also illuminates the origins of neurod

关 键 词：diet gut-brain axis microbiome neurodegenerative diseases NUTRITION Parkinson's disease PROGESTERONE steroid hormones 

分 类 号：R742.5[医药卫生—神经病学与精神病学]