Dynamics and functions of E‑cadherin complexes in epithelial cell and tissue morphogenesis  

作　　者：Na Zhang Matthias Häring Fred Wolf Jörg Großhans Deqing Kong 

机构地区：[1]Department of Biology,Philipps University,35043 Marburg,Germany [2]Göttingen Campus Institute for Dynamics of Biological Networks(CIDBN),Georg August University Göttingen,37073 Göttingen,Germany

出　　处：《Marine Life Science & Technology》2023年第4期585-601,共17页海洋生命科学与技术（英文）

基　　金：supported by the grants of the Deutsche Forschungsgemeinschaft(GR1945/10-1and GR1945/10-2 to JG)。

摘　　要：Cell–cell adhesion is at the center of structure and dynamics of epithelial tissue.E-cadherin–catenin complexes mediate Ca^(2+)-dependent trans-homodimerization and constitute the kernel of adherens junctions.Beyond the basic function of cell–cell adhesion,recent progress sheds light the dynamics and interwind interactions of individual E-cadherin–catenin complex with E-cadherin superclusters,contractile actomyosin and mechanics of the cortex and adhesion.The nanoscale architecture of E-cadherin complexes together with cis-interactions and interactions with cortical actomyosin adjust to junctional tension and mechano-transduction by reinforcement or weakening of specific features of the interactions.Although post-translational modifications such as phosphorylation and glycosylation have been implicated,their role for specific aspects of in E-cadherin function has remained unclear.Here,we provide an overview of the E-cadherin complex in epithelial cell and tissue morphogenesis focusing on nanoscale architectures by super-resolution approaches and post-translational modifications from recent,in particular in vivo,studies.Furthermore,we review the computational modelling in E-cadherin complexes and highlight how computational modelling has contributed to a deeper understanding of the E-cadherin complexes.

关 键 词：Nanoscale architectures PHOSPHORYLATION GLYCOSYLATION Computational modelling 

分 类 号：Q591.2[生物学—生物化学]