精神障碍生物诊断标志物研究的困惑与思考  

Rethinking on the study of diagnostic biomarker in psychiatric disorders

作　　者：李凌江[1] 柳进 Li Lingjiang;Liu Jin(Department of Psychiatry,the Second Xiangya Hospital of Central South University,National Clinical Research Center for Mental Disorders,National Center for Mental Disorders,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院精神病学科、国家精神心理疾病临床研究中心、国家精神疾病医学中心,长沙410011

出　　处：《中华精神科杂志》2024年第1期2-7,共6页Chinese Journal of Psychiatry

摘　　要：寻找特异性强、敏感性高、信效度好的生物诊断标志物是突破基于临床现象学分类的精神障碍诊断系统限制,实现精神障碍精准诊疗的重要途径。本文总结了当前精神障碍生物诊断标志物研究进展仍然相对滞后的原因和研究中的主要困惑,提出了突破当前精神障碍生物诊断标志物研究困境的思考,期待在新方法、新技术和新思路的加持下,精神障碍生物诊断标志物研究取得突破性进展。For mental disorders,identifying biomarkers with high specificity,sensitivity,and validity is an essential way to overcome systemic limitations of the diagnostic system based on clinical phenomenology and achieve precise treatment.In a nutshell,we pinpoint the primary reasons for the current delays in biomarker research for mental disorders and the main confusion and propose strategies to address the existing challenges.Integrating innovative approaches,new methods,and novel technologies will bolster the progress in this domain.

关 键 词：精神障碍 生物诊断标志物 异质性 遗传学 脑影像学 

分 类 号：R741[医药卫生—神经病学与精神病学]