Glycobiology in osteoclast differentiation and function  

作　　者：Shufa Yang Ziyi He Tuo Wu Shunlei Wang Hui Dai 

机构地区：[1]Prenatal Diagnostic Center,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China [2]Department of Immunology,School of Basic Medical Sciences,NHC Key Laboratory of Medical Immunology,Peking University,Beijing 100191,China

出　　处：《Bone Research》2023年第4期651-664,共14页骨研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant No.81972041);the Beijing Natural Science Foundation(grant No.7172112)。

摘　　要：Glycans,either alone or in complex with glycan-binding proteins,are essential structures that can regulate cell biology by mediating protein stability or receptor dimerization under physiological and pathological conditions.Certain glycans are ligands for lectins,which are carbohydrate-specific receptors.Bone is a complex tissue that provides mechanical support for muscles and joints,and the regulation of bone mass in mammals is governed by complex interplay between bone-forming cells,called osteoblasts,and bone-resorbing cells,called osteoclasts.Bone erosion occurs when bone resorption notably exceeds bone formation.Osteoclasts may be activated during cancer,leading to a range of symptoms,including bone pain,fracture,and spinal cord compression.Our understanding of the role of protein glycosylation in cells and tissues involved in osteoclastogenesis suggests that glycosylation-based treatments can be used in the management of diseases.The aims of this review are to clarify the process of bone resorption and investigate the signaling pathways mediated by glycosylation and their roles in osteoclast biology.Moreover,we aim to outline how the lessons learned about these approaches are paving the way for future glycobiology-focused therapeutics.

关 键 词：OSTEOCLAST ALONE FUNCTION 

分 类 号：R68[医药卫生—骨科学]