格隆溴铵立体异构体杂质的毛细管电泳测定——推荐一个药物分析实验  

Determination of Stereoisomeric Impurities of Glycopyrrolate Bromide by Capillary Electrophoresis:Recommendation of a Pharmaceutical Analysis Experiment

作　　者：李凤 孟然然 张含智 屈颖娟[1] 康经武 Feng Li;Ranran Meng;Hanzhi Zhang;Yingjuan Qu;Jingwu Kang(Xi’an Key Laboratory of Food Safety Testing and Risk Assessment,School of Chemical Engineering,Xi’an University,Xi’an 710065,China;State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;Abiochem Biotechnology Co.,Ltd.,Shanghai 200241,China)

机构地区：[1]西安文理学院化学工程学院,西安市食品安全检测与风险评估重点实验室,西安710065 [2]中国科学院上海有机化学研究所,生命过程小分子调控重点实验室,上海200032 [3]弈柯莱生物科技(上海)股份有限公司,上海200241

出　　处：《大学化学》2023年第12期67-74,共8页University Chemistry

基　　金：西安文理学院药物分析课程改革项目(JY2023KGC11);西安文理学院仪器分析MOOC课程改革项目(JY2022KGA05);国家自然科学基金(92053101,21175146)。

摘　　要：推荐了一个药物分析实验——手性毛细管电泳分析药物格隆溴铵的立体异构体。实验内容包括:环糊精手性选择剂的选择、毛细管电泳分离条件的优化、标准曲线的绘制等。本实验从药物分析的角度,重点介绍毛细管电泳分析方法、手性分离的原理及药物立体异构体杂质分析的重要性。建议在应用化学、药学及制药工程等专业开设。This article recommends a pharmaceutical analysis experiment“chiral capillary electrophoresis analysis of the stereoisomers of the drug Glycopyrrolate bromide”.The experiment includes the selection of cyclodextrin chiral selector,optimization of capillary electrophoresis separation conditions,and construction of a standard curve.From the perspective of pharmaceutical analysis,this experiment focuses on introducing the principle of capillary electrophoresis analysis,the principle of chiral separation,and the importance of analyzing stereoisomeric impurities in drugs.It is suggested to be offered in majors such as applied chemistry,pharmacy,and pharmaceutical engineering.

关 键 词：毛细管电泳 手性分析 格隆溴铵 环糊精 药物分析实验 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]