New insights into astrocyte diversity from the lens of transcriptional regulation and their implications for neurodegenerative disease treatments  

作　　者：Ibrahim Olabayode Saliu Guoyan Zhao 

机构地区：[1]Department of Genetics,Washington University School of Medicine,St.Louis,MO,USA [2]Department of Neurology,Department of Pathology and Immunology,Washington University School of Medicine,St.Louis,MO,USA

出　　处：《Neural Regeneration Research》2024年第11期2335-2336,共2页中国神经再生研究（英文版）

基　　金：supported in part by the R21AG077643,R01NS123571,1U19NS130607,and 5T U24 HG012070(to GZ);in part by Alzheimer Association Fellowship Award 23AARFD-1029969(to IOS).

摘　　要：Astrocytes are a major glial cell type in the central nervous system,and they provide trophic and metabolic support to neurons.In addition to these roles,they play crucial roles in modulating synaptic functions,development,and pruning(Brandebura et al.,2023).Astrocytes become reactive(activated)by undergoing morphological,molecular,and functional alterations in response to neuropathology such as in injuries and neurodegenerative diseases(NDs)(Escartin et al.,2021).

关 键 词：DEGENERATIVE INJURIES 

分 类 号：R741[医药卫生—神经病学与精神病学]