Neurogenesis in primates versus rodents and the value of non-human primate models  

作　　者：Runrui Zhang Hongxin Quan Yinfeng Wang Fucheng Luo 

机构地区：[1]State Key Laboratory of Primate Biomedical Research,Institute of Primate Translational Medicine,Kunming University of Science and Technology,Kunming 650500,China [2]Yunnan Key Laboratory of Primate Biomedical Research,Kunming 650500,China

出　　处：《National Science Review》2023年第11期56-78,共23页国家科学评论（英文版）

基　　金：supported by the National Natural Science Foundation of China(32070864 and 82060234);the STI2030-Major Projects(2022ZD0207700);the Xingdian Talent Support Program(KKRD202273100);the Natural Science Foundation of Yunnan Province(202001BC070001 and 202102AA100053).

摘　　要：Neurogenesis, the process of generating neurons from neural stem cells, occurs during both embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction in either stage can disrupt normal neural development, impair cognitive functions, and lead to various neurological disorders. Recent technological advancements in single-cell multiomics and gene-editing have facilitated investigations into primate neurogenesis. Here, we provide a comprehensive overview of neurogenesis across rodents, non-human primates, and humans, covering embryonic development to adulthood and focusing on the conservation and diversity among species. While non-human primates, especially monkeys, serve as valuable models with closer neural resemblance to humans, we highlight the potential impacts and limitations of non-human primate models on both physiological and pathological neurogenesis research.

关 键 词：RODENT PRIMATE embryonic neurogenesis adult neurogenesis 

分 类 号：R741[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]