非酒精性单纯性脂肪肝患者肠道菌群状况与动脉粥样硬化的相关性  

Relationship between Intestinal Flora and Atherosclerosis in Patients with Nonalcoholic Simple Fatty Liver Disease

作　　者：王友清[1] WANG Youqing(Department of Infectious Diseases,Yellow River Sanmenxia Hospital,Sanmenxia,Henan Province,472000 China)

机构地区：[1]黄河三门峡医院感染性疾病科,河南三门峡472000

出　　处：《系统医学》2023年第24期34-37,共4页Systems Medicine

摘　　要：目的探讨与分析非酒精性单纯性脂肪肝患者肠道菌群状况与动脉粥样硬化的相关性。方法连续收集2021年3月—2022年12月在黄河三门峡医院诊治的非酒精性单纯性脂肪肝患者72例作为研究对象,其中单纯非酒精性单纯性脂肪肝患者36例(对照组),非酒精性单纯性脂肪肝合并动脉粥样硬化患者36例(合并组),检测两组的肠道菌群状况,判断动脉粥样硬化发生情况并进行相关性分析。结果在合并组中,冠状动脉、颈动脉、双下肢动脉粥样硬化发生率分别为30.56%(11/36)、44.44%(16/36)、25.00%(9/36),其中Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级分别为20例、8例、4例、4例。合并组的乳杆菌属相对含量显著低于对照组(P<0.05),酵母菌样真菌、肠球菌属相对含量显著高于对照组,差异有统计学意义(P均<0.05)。合并组不同动脉粥样硬化狭窄程度患者的肠道菌群相对含量对比,差异有统计学意义(P均<0.05)。Spearman分析显示动脉粥样硬化程度与乳杆菌属含量呈现负相关,与酵母菌样真菌和肠球菌属含量呈现正相关(r=-0.674、0.733、0.792,P均<0.05)。结论合并动脉粥样硬化的非酒精性单纯性脂肪肝患者的发病部位多样化,多伴随肠道菌群紊乱,动脉粥样硬化程度与肠道菌群相对含量都存在相关性。Objective To explore and analyze the relationship between intestinal flora and atherosclerosis in patients with nonalcoholic simple fatty liver disease.Methods A total of 72 patients with non-alcoholic simple fatty liver dis⁃ease who were treated and treated in Yellow River Sanmenxia Hospital from March 2021 to December 2022 were col⁃lected as the study objects.There were 36 patients with simple nonalcoholic fatty liver disease(control group)and 36 patients with nonalcoholic simple fatty liver disease complicated with atherosclerosis(combined group).The intestinal flora of the two groups were detected to determine the occurrence of atherosclerosis and correlation analysis was per⁃formed.Results In the combined group,the incidence of coronary artery,carotid artery and lower limb atherosclerosis was 30.56%(11/36),44.44%(16/36)and 25.00%(9/36),respectively.Among them,gradeⅠ,Ⅱ,ⅢandⅣwere 20,8,4 and 4 cases,respectively.The relative content of Lactobacillus in the combined group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The relative contents of yeast-like fungi and Enterococcus were significantly higher than those in control group,and the differences were statistically sig⁃nificant(both P<0.05).There were also statistically significant differences in the relative content of intestinal flora in patients with different atherosclerotic stenosis in the combined group(all P<0.05).Spearman analysis showed that the degree of atherosclerosis was negatively correlated with the contents of Lactobacillus,and positively correlated with the contents of yeast-like fungi and Enterococcus(r=-0.674,0.733,0.792,all P<0.05).Conclusion Patients with non⁃alcoholic fatty liver disease complicated with atherosclerosis have a variety of sites and are often accompanied by in⁃testinal flora disorders.There is a correlation between the degree of atherosclerosis and the relative content of intesti⁃nal flora.

关 键 词：非酒精性单纯性脂肪肝 动脉粥样硬化 肠道菌群 血脂 相关性 乳杆菌 

分 类 号：R575.5[医药卫生—消化系统]