Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers  

作　　者：Cao Dai Lin Peng Yanjie Li Zhendong Li Da Chen Fei Wang Nan Lin 

机构地区：[1]Department of Hepatobiliary Surgery,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China [2]School of Environment,Guangdong Key Laboratory of Environmental Pollution and Health,Jinan University,Guangzhou 510632,China [3]State Key Laboratory of Environmental and Biological Analysis,Department of Chemistry,Hong Kong Baptist University,Hong Kong 999077,China [4]South China Institute of Environmental Sciences,MEE,Guangzhou 510655,China

出　　处：《Journal of Environmental Sciences》2024年第5期418-427,共10页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.42177408);Guangdong(China)Innovative and Entrepreneurial Research Team Program(No.2016ZT06N258)。

摘　　要：Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood samples.Besides,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers levels.For example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with age.In addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.

关 键 词：Per-and polyfluoroalkyl substances(PFASs) Liver cancer SERUM BLOOD URINE Liver function biomarkers 

分 类 号：R735.7[医药卫生—肿瘤] X503.1[医药卫生—临床医学]