植物sirtuin蛋白家族研究进展  

Research Progress in Sirtuin Protein Family in Plants

作　　者：苏鲁方 王萍 李顺 蔡燕 郭丹丹 刘琴[1] 刘小云 Lufang Su;Ping Wang;Shun Li;Yan Cai;Dandan Guo;Qin Liu;Xiaoyun Liu(School of Life Sciences,Jianghan University,Wuhan 430056,China)

机构地区：[1]江汉大学生命科学学院,武汉430056

出　　处：《植物学报》2023年第6期998-1007,共10页Chinese Bulletin of Botany

基　　金：湖北省自然科学基金(No.2023AFB982);江汉大学新学科专项(No.2022ZX-3-03)和江汉大学大学生创新创业重点项目(No.2021zd165)。

摘　　要：植物sirtuin蛋白家族是一类依赖β-烟酰胺腺嘌呤二核苷酸(β-NAD+)、分别催化非组蛋白和组蛋白赖氨酸上N^(ε)-乙酰基和N^(ε)-酰基(乙酰基、巴豆酰基、丁酰基和2-羟基异丁酰基)去除的酶,具有调控非组蛋白活性和基因表达的功能。已证明sirtuin蛋白家族成员在水稻(Oryza sativa)、大豆(Glycine max)和番茄(Solanum lycopersicum)等植物的生长发育以及盐、冷、热和病原菌等胁迫响应中发挥重要的表观调控作用。该文对植物sirtuins的酶活性、催化底物、细胞定位和功能进行综述,为理解其表观遗传调控机制及丰富新功能研究提供参考。The sirtuin protein family of plants is a class of enzymes that depend onβ-nicotinamide adenine dinucleotide(β-NAD+)to catalyze the removal of N^(ε)-acetyl and N^(ε)-acyl(acetyl,crotonyl,butylyl and 2-hydroxy-isobutylyl)from non-histone and histone lysine,respectively,and has the function of regulating the activity of non-histone protein and gene expression.Members of the sirtuin protein family have been shown to play important epigentic regulatory roles in the growth and development of rice(Oryza sativa),soybean(Glycine max)and tomato(Solanum lycopersicum),and in response to salt,cold,heat and pathogen stresses.Here we summarized the recent research advances in the enzyme activity,catalytic substrates,cell localization and function of plant sirtuins,which will serve as a reference for understanding the epigenetic regulation mechanism and studying the new function of sirtuin.

关 键 词：植物 SIRTUINS 去酰基 表观遗传调控 发育 胁迫 

分 类 号：Q946[生物学—植物学]