海博麦布结构确证  

Structural Elucidation of Hybutimibe

作　　者：徐肖杰 陈延安 李旭飞 张云才 张勇 詹冬凯 潘婷 XU Xiaojie;CHEN Yan’an;LI Xufei;ZHANG Yuncai;ZHANG Yong;ZHAN Dongkai;PAN Ting(Zhejiang Hisun Pharmaceutical Co.,LTD,Taizhou 318000,China)

机构地区：[1]浙江海正药业股份有限公司,浙江台州318000

出　　处：《波谱学杂志》2024年第1期43-55,共13页Chinese Journal of Magnetic Resonance

基　　金：“十二五”“重大新药创制”科技重大专项项目(2013ZX09402101).

摘　　要：本文采用紫外吸收光谱、红外吸收光谱、质谱、核磁共振波谱(包含^(1)HNMR、^(13)CNMR、DEPT、^(1)H-^(1)H COSY、^(1)H-^(1)HNOESY、^(1)H-^(13)CHSQC和^(1)H-^(13)CHMBC)以及单晶衍射等方法对海博麦布进行结构分析,对其所有的^(1)HNMR和^(13)CNMR谱信号进行了归属,还通过差示扫描量热法、热重分析及粉末X-射线衍射分析对海博麦布晶型进行研究.The structure of hybutimibe was analyzed by ultraviolet absorption spectroscopy,infrared absorption spectroscopy,mass spectrometry,nuclear magnetic resonance(^(1)H NMR,^(13)C NMR,DEPT,^(1)H-^(1)H COSY,^(1)H-^(1)H NOESY,^(1)H-^(13)C HSQC and ^(1)H-^(13)C HMBC)spectroscopy and single crystal diffraction.The ^(1)H and ^(13)C NMR signals of hybutimibe were assigned.The crystal structure of hybutimibe was studied by differential scanning calorimetry(DSC),thermogravimetric analysis(TGA)and powder X-ray diffraction(PXRD).

关 键 词：海博麦布 核磁共振 质谱 红外吸收光谱 结构确证 

分 类 号：TQ460.1[化学工程—制药化工]