膳食维生素摄入与胶质瘤关联性的病例对照研究  

Associations between dietary vitamin andglioma:a case-control study based on Chinese

作　　者：王磊[1] 张维春柏 庄维维 王婵媛 郭伟[1] 易晓平 韩丽军[1] WANG Lei;ZHANG Wei-chun-bai;ZHUANG Wei-wei;WANG Chan-yuan;GUO Wei;YI Xiao-ping;HAN Li-jun(Departent of Comprehensive Neuro-Oncology Treatment,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经肿瘤综合治疗,北京100070

出　　处：《现代预防医学》2024年第4期619-624,共6页Modern Preventive Medicine

基　　金：北京天坛医院人才引进(RCYJ-2020-LWB);2020年国家和省级临床重点专科能力建设项目。

摘　　要：目的 了解中国人群中膳食维生素A、维生素C和维生素E与胶质瘤的关系。方法 基于1:1个体匹配的病例对照研究,对343例胶质瘤患者和343例健康对照进行问卷调查和体格测量,通过食物频率问卷评估三种膳食维生素的摄入量,采用logistic回归分析膳食维生素摄入量与胶质瘤风险的关联性,并探索二者之间的剂量-反应关系。结果 与最低分位数相比,最高分位数的膳食维生素A摄入量与胶质瘤总体风险(OR=0.10,95%CI:0.04~0.30)、星形细胞瘤风险(OR=0.71,95%CI:0.59~0.86)、胶质母细胞瘤风险(OR=0.86,95%CI:0.78~0.96)、低级别胶质瘤风险(OR=0.65,95%CI:0.47~0.91)和高级别胶质瘤风险(OR=0.87,95%CI:0.80~0.94)降低有关,最高分位数的膳食维生素C摄入量与胶质瘤总体风险(OR=0.02,95%CI:0.01~0.08)、星形细胞瘤风险(OR=0.69,95%CI:0.54~0.87)、胶质母细胞瘤风险(OR=0.82,95%CI:0.74~0.91)、低级别胶质瘤风险(OR=0.75,95%CI:0.62~0.91)和高级别胶质瘤风险(OR=0.79,95%CI:0.72~0.86)降低有关.但膳食维生素E摄入量仅与星形细胞瘤风险升高有关(OR=2.99,95%CI:1.23~7.30)。膳食维生素A和维生素C摄入量与胶质瘤风险之间存在显著的剂量-反应关系。结论 摄入较多的膳食维生素A和维生素C可能与胶质瘤风险降低相关,但维生素E对不同临床亚型的胶质瘤的影响并不一致。在未来,应通过前瞻性研究进一步验证这些膳食维生素与胶质瘤的关联性。Objective To understand the relationship between dietary vitamins A,vitamin C and vitamin E and glioma in Chinese population.Methods Based on the case-control study of 1:1 individual matched,a questionnaire survey was carried out on 343 patients with glioma and 343 healthy controls.The intake of three dietary vitamins was evaluated through the food frequency questionnaire,and the intake of dietary vitamins and gloima was analyzed by logistic regression,and explored the dose-response relationship between the two.Results Compared with the lowest quantile,the highest quantile of dietary vitamin A intake was associated with a decrease in overall glioma risk(OR=0.10,95%CI:0.04-0.30),astrocytoma risk(OR=0.71,95%CI:0.59-0.86),glioblastoma risk(OR=0.86,95%CI:0.78-0.96),low-grade glioma risk(OR=0.65,95%CI:0.47-0.91),and high-grade glioma risk(OR=0.87,95%CI:0.80-0.94).The highest quantile of dietary vitamin C intake was associated with a decrease in overall glioma risk(OR=0.02,95%CI:0.01-0.08),astrocytoma risk(OR=0.69,95%CI:0.54-0.87),glioblastoma risk(OR=0.82,95%CI:0.74-0.91),low-grade glioma risk(OR=0.75,95%CI:0.62-0.91)and high-grade glioma risk(OR=0.79,95%CI:0.72-0.86).However,dietary vitamin E intake was only associated with an increased risk of astrocytoma(OR=2.99,95%CI:1.23-7.30).There was a significant linear dose-reaction relationship between the two,but the results of vitamin E were inconsistent and should be treated with caution.Conclusion High intake of dietary vitamin A and vitamin C may be associated with a reduced risk of glioma,but the impact of vitamin E on different clinical subtypes of glioma is not consistent.In the future,prospective studies should be conducted to further verify the association between these dietary vitamins and glioma.

关 键 词：胶质瘤 膳食调查 维生素 神经肿瘤护理 

分 类 号：R739.4[医药卫生—肿瘤]