生理性睡眠觉醒的潜在调节机制  

The regulatory mechanism of physiological sleep-wake

作　　者：卢维杰 吴国泰 刘凯 赵信科 李倩蓉 李应东 LU Wei-jie;WU Guo-tai;LIU Kai;ZHAO Xin-ke;LI Qian-rong;LI Ying-dong(College of Integrated Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000 [2]甘肃中医药大学药学院,甘肃兰州730000

出　　处：《中国药理学通报》2024年第3期421-426,共6页Chinese Pharmacological Bulletin

基　　金：国家重点研发计划资助项目(No2018YFC1705604)。

摘　　要：该文从睡眠昼夜节律系统和睡眠稳态系统两个方面,解释生理性睡眠与觉醒相互切换的机制。在昼夜节律系统当中,以视交叉上核为核心,汇总了其与影响睡眠的各系统之间的解剖联系,归纳出自视交叉上核始,经下丘脑室下区、视前区腹外侧核、食欲素神经元、褪黑素系统4条通路,并阐述了其调控睡眠觉醒的相关机制;在睡眠稳态系统中,以腺苷、前列腺素D2为靶点,阐述了催眠原在睡眠觉醒调控中的机制。This paper explains the mechanism of the mutual switching between physiological sleep and wakefulness from the aspects of the sleep circadian system and the sleep homeostasis system.In the circadian rhythm system,with the suprachiasmatic nucleus as the core,the anatomical connections between the suprachiasmatic nucleusand various systems that affect sleep are summarized,starting from the suprachiasmatic nucleus,passing through the four pathways of the melatonin system,namely,subventricular area of the hypothalamus,the ventrolateral nucleus of the preoptic area,orexin neurons,and melatonin,then the related mechanisms of their regulation of sleep and wakefulness are expounded.In the sleep homeostasis system,with adenosine and prostaglandin D2 as targets,the role of hypnogen in sleep arousal mechanisms in regulation is also expounded.

关 键 词：睡眠觉醒 调节机制 睡眠昼夜节律系统 睡眠稳态系统 视交叉上核 催眠原 

分 类 号：R-05[医药卫生] R322.85R338.63