Efficacy of borneol-gypsum in skin regeneration and pain control in toxic epidermal necrolysis:A case report  

作　　者：Lu-Wei Yang Li-Juan Zhang Bin-Bin Zhou Xin-Yu Lin Yu-Ting Chen Xiao-Yu Qin Hui-Ying Tian Li-Li Ma Ying Sun Lin-Di Jiang 

机构地区：[1]Department of Rheumatology,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361100,Fujian Province,China [2]Department of Dermatology,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361100,Fujian Province,China [3]Department of Ophthalmology,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361100,Fujian Province,China [4]Department of Nursing,Zhongshan Hospital(Xiamen),Fudan University,Xiamen 361100,Fujian Province,China [5]Department of Rheumatology,Zhongshan Hospital,Fudan University,Shanghai 200030,China

出　　处：《World Journal of Clinical Cases》2024年第7期1290-1295,共6页世界临床病例杂志

摘　　要：BACKGROUND Toxic epidermal necrolysis(TEN)is a life-threatening dermatological emergency mainly induced by drug hypersensitivity reactions.Standard management includes discontinuation of culprit drug and application of immunomodulatory therapy.However,mortality remains high due to complications like septic shock and multiorgan failures.Innovative approaches for skin care are crucial.This report introduces borneol-gypsum,a traditional Chinese drug but a novel dressing serving as an adjuvant of TEN therapy,might significantly improve skin conditions and patient outcomes in TEN.CASE SUMMARY A 38-year-old woman diagnosed with eosinophilic granulomatosis with polyangiitis experienced gangrenous complications and motor nerve involvement.After initial treatment of high-dose corticosteroids and cyclophosphamide,symptom of foot drop improved,absolute eosinophil counts decreased,while limb pain sustained.Duloxetine was added to alleviate her symptom.Subsequently,TEN developed.Additional topical application of borneol-gypsum dressing not only protected the skin lesions from infection but also significantly eased localized pain.This approach demonstrated its merit in TEN management by promoting skin healing and potentially reducing infection risks.CONCLUSION Borneol-gypsum dressing is a promising adjuvant that could significantly improve TEN management,skin regeneration,and patient comfort.

关 键 词：Toxic epidermal necrolysis Eosinophilic granulomatosis with polyangiitis DULOXETINE BORNEOL GYPSUM Case report 

分 类 号：R751[医药卫生—皮肤病学与性病学]