BACKGROUND Toxic epidermal necrolysis(TEN)is a life-threatening dermatological emergency mainly induced by drug hypersensitivity reactions.Standard management includes discontinuation of culprit drug and application o...
supported by Brazilian Federal Agency Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES)for PhD grants(No.99999.000845/2014-00);Fundacao para a Ciência e a Tecnologia(FCT)Portugal(Projects UID/MULTI/00612/2013,PEst-OE/QUI/UI0612/2013 and LISBOA-01-0145-FEDER-022125)
Duloxetine(DUL), an antidepressant drug, has been detected in surface water and wastewater effluents, however, there is little information on the formation of its transformation products(TPs). In this work, hydrolysis...
BACKGROUND AND OBJECTIVE Multimodal analgesia is the main strategy used for post-operative pain management, with opioidsthought to remain necessary to treat moderate to severe pain. Selective serotonin and norepinephr...
The electrochemical behavior of duloxetine HCl (DXT.HCl) at a carbon paste electrode (CPE) was achieved by cyclic voltammetry and a mechanism of its oxidation was reported and illustrated. A sensitive linear sweep and...
Objective: Chemotherapy with paclitaxel is associated with significant neurotoxicity that may offset patients' quality of life and therapeutic benefits. This prospective, non-randomized control study evaluated the e...
The main purpose of the present study was to prepare duloxetine hydrochloride(DXH) entericcoated pellets using different enteric polymers. Three layers(drug-loaded layer, barrier layer,and enteric-coated layer) were a...
Aim: The selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SNRIs) are commonly used for the treatment of neuropathic pain and fibromyalgia. Ammoxetine ((±)-3-(benzo[d] [1,3]dioxol-4-y...
Cancer-related fatigue(CRF)is a common polysymptomatic syndrome with no standard therapy.The authors present the case of a prostate cancer patient in whom,during hormone therapy,disabling CRF and urinary incontinence ...
Background: Major depressive disorder is a serious public health problem affecting the lives of millions in the worldwide and leading causes of disability and disease. This study aimed to evaluate the efficacy and saf...