茯砖茶上调秀丽隐杆线虫NHR-49和ACO基因促进脂质分解代谢  

Fuzhuan Tea Promotes the Lipid Catabolism Via Upregulation NHR-49 and ACO in Caenorhabditis Elegans

作　　者：潘联云 刘本英[1] PAN Lianyun;LIU Benying(Tea Research Institute,Yunnan Academy of Agricultural Sciences/Yunnan Provincial Key Laboratory of Tea Science,Menghai 666200,China)

机构地区：[1]云南省农业科学院茶叶研究所/云南省茶学重点实验室,云南勐海666200

出　　处：《茶叶通讯》2024年第1期78-84,共7页Journal of Tea Communication

基　　金：云南省茶学重点实验室开放基金项目(2020YNCX005)。

摘　　要：茯砖茶通过抑制脂质合成的降脂作用已在多项研究中报道,而关于其调控脂质分解代谢的研究还较少。以秀丽隐杆线虫为模式生物,通过脂质染色、突变体、RNA干扰和qPCR检测分析茯砖茶水提物对秀丽隐杆线虫脂质分解代谢的调控作用及其机制。研究发现,茯砖茶水提物能够通过上调核激素受体nhr-49和顺乌头酸酶aco-1的基因表达提高脂肪酸β氧化和三羧酸循环,促进脂质氧化分解,从而减少秀丽隐杆线虫脂肪含量。The lipid-reducing effects of Fuzhuan tea by inhibiting lipid synthesis have been reported in a number of studies,there are few studies on its regulation of lipid catabolism.In this study,we used Caenorhabditis elegans as model organisms,and analyzed the function and regulatory mechanism of Fuzhuan brick tea extract(FBTE)on lipid decomposition in C.elegans via by lipid staining,mutants,RNA interference and qPCR.We found that FBTE improved the fatty acidβ-oxidation and the tricarboxylic acid cycle,and promoted the lipid catabolism by upregulating the expression nhr-49 and aco-1 in C.elegans,thereby reduced the fat storage.

关 键 词：茯砖茶 脂肪酸β氧化 三羧酸循环 脂质分解 脂质代谢 

分 类 号：S571.1[农业科学—茶叶生产加工] TS272[农业科学—作物学]