脱氧雪腐镰刀菌烯醇解毒酶研究进展  

Research Advances in Enzymatic Detoxification of Deoxynivalenol

作　　者：孙晶 赵程程 杜稳 韩杨莹 赵一凡 刘虎军 SUN Jing;ZHAO Cheng-cheng;DU Wen;HAN Yang-ying;ZHAO Yi-fan;LIU Hu-jun(Institute of Cereal and Oil Science and Technology,Academy of National Food and Strategic Reserves Administration,Beijing 100037,China)

机构地区：[1]国家粮食和物资储备局科学研究院粮油加工研究所,北京100037

出　　处：《粮油食品科技》2024年第2期121-126,共6页Science and Technology of Cereals,Oils and Foods

基　　金：中央级公益性科研院所基本科研业务费专项(JY2208)。

摘　　要：脱氧雪腐镰刀菌烯醇(Deoxynivalenol,DON)是镰刀菌属(Fusariums spp.)产生的剧毒次级代谢产物,主要污染小麦、玉米等粮食及其制品,导致了严重的食品安全风险。目前生物酶法去除DON的技术研究,展现出良好的应用前景。综述了国内外关于DON生物转化的生物酶类型、降解机制、产物结构特征、解毒酶挖掘策略,以及解毒酶分子改造等研究现状,并对人工智能应用于真菌毒素解毒酶的相关研究进行了展望,以期为食品和饲料中DON的生物脱毒技术的研发提供参考。Deoxynivalenol(DON) is a toxic secondary metabolite produced by Fusarium spp.that mainly contaminates wheat,corn,and other food crops,and has posed serious threats to food safety.Currently,enzymatic detoxification of DON shows promising application prospects.This paper provided an overview of the latest domestic and international research on the types of biotransformation enzymes,degradation mechanisms,structural features,detoxification enzyme mining strategies,and molecular modifications of DON.Additionally,the paper explored research trends in molecular design of mycotoxin detoxification enzymes assisted by artificial intelligence,which aimed to provide a reference for the development of bio-detoxification technology of DON in food and feed.

关 键 词：脱氧雪腐镰刀菌烯醇 生物酶 生物降解 分子改造 食品安全 

分 类 号：Q814[生物学—生物工程]