Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation  

作　　者：Hean Teik Ong Jinghong Chen 

机构地区：[1]Cardiology,HT Ong Heart Clinic Georgetown,Penang,Malaysia [2]Editorial Office of General Psychiatry,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《General Psychiatry》2023年第6期454-462,共9页综合精神医学（英文）

摘　　要：Increasing observational and experimental trial data have shownthat mental stress can lead toan increase in adverse clinical cardiovascular events.Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction(MI)or direct myocardial injury.Mental stress leads to systemic inflammation.Inflammation is known to cause rapid atheromatous plaque progression,instability and thrombosis—the classic type 1 MI.Inflammation can also lead to type 2 MI or myocarditis and injury.The published data linking systemic inflammation,mental stress and cardiovascular disease will be reviewed to establish the linkage between mind and heart,thereby highlighting the importance of holistically managing the patient,not only addressing separate organ systems.Finally,recent trial evidence showing the value of anti-inflammatory drugs in cardiovascular and mental conditions will be briefly considered.

关 键 词：INFLAMMATION DRUGS STRESS 

分 类 号：R54[医药卫生—心血管疾病] R749[医药卫生—内科学]