Acute effect of twice-daily 15 mA transcranial alternating current stimulation on treatment-resistant depression: a case series study  

作　　者：Wenfeng Zhao Huang Wang Haixia Leng Qing Xue Mao Peng Xiukun Jin Liucen Tan Na Pan Xuedi Wang Jie Wang Keming Gao Xiangyang Zhang Hongxing Wang 

机构地区：[1]Department of Neurology,Beijing Psychosomatic Disease Consultation Center,National Center for Neurological Disorders,National Clinical Research Center for Geriatric Diseases,Xuanwu Hospital Capital Medical University,Beijing,China [2]Key Laboratory of Magnetic Resonance in Biological Systems,State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,National Center for Magnetic Resonance in Wuhan,Wuhan Institute of Physics and Mathematics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics,Wuhan,China [3]University of the Chinese Academy of Sciences,Beijing,China [4]Department of Psychiatry,University Hospitals Cleveland Medical Center,Cleveland,Ohio,USA [5]CAS Key Laboratory of Mental Health,Chinese Academy of Sciences,Beijing,China [6]Beijing Institute for Brain Disorders,Beijing,China [7]Institute of Special Medical Sciences,School of Forensic Medicine,Shanxi Medical University,Taiyuan,China

出　　处：《General Psychiatry》2023年第6期547-551,共5页综合精神医学（英文）

基　　金：supported by the National Natural Science Foundation of China(82371490);the National Key R&D Program of China(2022YFC2503901,2022YFC2503900);the Beijing Hundred,Thousand,and Ten Thousand Talents Project(2017-CXYF-09);Beijing Health System Leading Talent Grant(2022-02-10).

摘　　要：Totheeditor:Major depressive disorder(MDD)is a principal cause of disability worldwide and is often associated with high morbidity and mortality rates.Although there are several therapies available for the treatment of depression,about one-third of patients with MMD will not respond to two or more antidepressant drugs with different mechanisms;the patients are then referred to as having treatment-resistant depression(TRD).Patients with TRD have a poorer quality of life,greater economic burden and increased suicidal behaviours.Therefore,new antidepressant treatments that are effective,safe,long-lasting and tolerable are needed.Ketamine infusion,intranasal esketamine and transcranial magnetic stimulation(TMS)have been used to treat early stage TRD.’A recent review suggests that electroconvulsive therapy(ECT)may be superior to ketamine for reducing depression severity in the acute treatment of TRD.

关 键 词：STIMULATION TRANSCRANIAL TREATMENT 

分 类 号：R749.05[医药卫生—神经病学与精神病学]